Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
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United States of America Patent
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Nov 6, 2001
Grant Date -
N/A
app pub date -
Dec 30, 1999
filing date -
Jan 7, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise ##STR1## Wherein: R.sub.1, R.sub.2 and R.sub.3 are each, independently, hydrogen, halogen, CF.sub.3, alkyl, alkoxy, MeSO.sub.2, or together can form a 5-7 membered carbocyclic or heterocyclic ring; R.sub.4 is hydrogen, halogen, or alkyl; R.sub.5 is hydrogen, alkyl, alkylaryl, or aryl; R.sub.6 is hydrogen, halogen, CF.sub.3, CN, carbamide, or alkoxy; X.sub.1, X.sub.2 and X.sub.3 are each carbon or one of X.sub.1, X.sub.2 or X.sub.3 may be nitrogen; Y is carbon or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.
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