Polypeptides for promoting cell attachment
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United States of America Patent
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Nov 13, 2001
Issued Date -
N/A
app pub date -
Dec 1, 1998
filing date -
Dec 3, 1990
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Expired
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Abstract
Novel polypeptides derived from human fibronectin are described which bind to integrin receptors expressed by cells. The receptor binding site of human fibronectin begins at amino acid residue 1394 and ends at residue 1400 of fibronectin. The polypeptides facilitate attachment of cells to substrates either alone or in conjunction with RGD-containing peptides. Vectors, fusion proteins and antibodies are also described. Methods for promoting cell attachment and for inhibiting cell adhesion are also described.
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