Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha
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United States of America Patent
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Nov 20, 2001
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app pub date -
Dec 17, 1998
filing date -
Dec 19, 1997
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Abstract
Chemically modified tetracyclines are a new class of non-steroidal anti-inflammatory drugs which inhibit cyclooxygenase-2 and tumor necrosis factor alpha. These chemically modified tetracyclines are used in a method for inhibiting COX-2, which in turn inhibits PGE.sub.2, and/or inhibiting TNF.alpha.. They are also used in a method for treating a disease or disorder associated with elevated activities of COX-2 (i.e., increased production of PGE.sub.2) and/or TNF.alpha..
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