Compositions and methods for reversibly increasing permeability of biomembranes
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United States of America Patent
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Nov 20, 2001
Grant Date -
N/A
app pub date -
Apr 10, 2000
filing date -
Jul 9, 1997
priority date (Note) -
Expired
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Abstract
The present invention provides a family of branched fatty acids and their derivatives, which improve and enable the penetration and absorption of active ingredients through biomembranes, such as blood brain barrier. The invention further provides pharmaceutical compositions comprising these branched fatty acids and methods of using these compositions to permeabilize biological membranes thereby improving the administration of bioactive or therapeutic substances to cells or organs. According to a more preferred embodiment of this invention the methods are particularly useful to treat certain kinds of CNS lesions and diseases including tumors, infections, abscesses and degenerative and behavioral disorders.
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