HLA-restricted hepatitis B virus CTL epitopes
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United States of America Patent
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Nov 27, 2001
Issued Date -
N/A
app pub date -
Jun 5, 1995
filing date -
Aug 26, 1991
priority date (Note) -
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Abstract
Cytotoxic T lymphocyte-stimulating peptides induce HLA-restricted responses to hepatitis B virus antigens. The peptides, derived from CTL epitopic regions of both HBV surface and nucleocapsid antigens, are particularly useful in the treatment and prevention of HBV infection, including the treatment of chronically infected HBV carriers. The peptides can be formulated as HBV vaccines and pharmaceutical compositions, such as lipid-containing compositions for enhancing the HLA-restricted CTL responses. The peptides are also useful in diagnostic methods, such as predicting which HBV-infected individuals are prone to developing chronic infection.
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