Recombinant human beta-CIS interferon
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United States of America Patent
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Nov 27, 2001
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app pub date -
Jul 13, 1999
filing date -
Dec 18, 1996
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Abstract
The invention provides a new human interferon (IFN)-.beta. variant cloned from an amniotic cell library, a cDNA encoding it, and processes for its production and purification. The variant, termed interferon beta-cis, differs from previously known hIFN-.beta. isoforms by the substitution of a Cys residue for the Tyr present at position 60. Recombinant IFN beta-cis exhibits antiviral activity characteristic of IFN-.beta..
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