Enteric coated pharmaceutical tablet and method of manufacturing
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United States of America Patent
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-
Dec 18, 2001
Issued Date -
N/A
app pub date -
Apr 14, 2000
filing date -
Jul 17, 1998
priority date (Note) -
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status (Latency Note)
Importance
Abstract
A high drug load enteric coated pharmaceutical composition is provided which includes a core in the form of a tablet and which is comprised of a medicament which is sensitive to a low pH environment of less than 3, such as ddl, and having an enteric coating formed of methacrylic acid copolymer and a plasticizer. The tablets may be of varying sizes and may be orally ingested individually or a plurality of tablets sufficient to attain a desired dosage may be encapsulated in a dissolvable capsule. The tablets have excellent resistance to disintegration at pH less than 3 but have excellent drug release properties at pH greater than 4.5. A novel method of making said pharmaceutical composition is also disclosed.
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