Compositions of solvents and high concentrations of nucleic acid analogs
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United States of America Patent
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Dec 18, 2001
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N/A
app pub date -
May 13, 1999
filing date -
May 13, 1999
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Abstract
The invention provides compositions and methods suitable for dissolving nucleic acid analogs with uncharged, neutral backbones at high concentrations at approximately neutral pH. By using the compositions of the invention, which include a polar, aprotic solvent, concentrations of nucleic acid analogs such as PNA can be achieved in the range of approximately 1 .mu.M to 10 mM.
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