US Patent No: 6,335,033
Number of patents in Portfolio can not be more than 2000
Melt-extrusion multiparticulates
Stats
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Jan 1, 2002
Issued date -
Jul 22, 1999
filing date -
09/358,828
serial no -
In Force
status
Importance
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Abstract
A unit dose sustained-release oral dosage form containing a plurality of melt-extruded particles, each consisting essentially of a therapeutically active agent, one or more retardants, and an optional water-insoluble binder is disclosed. The particles have a length of from about 0.1 to about 12 mm and can be of varying diameters and each unit dose provides a release of therapeutically active agents over at least about 8 hours. Methods of preparing the unit doses as well as extrusion processes and methods of treatment are also disclosed.
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First Claim
Related Publications
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International Classification(s)
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- [Patents Count]
Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 4,483,847 Process for the manufacture of a pharmaceutical composition with a retarded liberation of active material | 62 | 1983 | |
| 4,778,676 Confectionery delivery system for actives | 60 | 1985 | |
| 4,882,153 Confectionery delivery system for antitussives | 21 | 1988 | |
| 4,879,108 Confectionery delivery system for antipyretics | 60 | 1988 | |
| 4,882,151 Confectionery delivery system for antihistimines | 13 | 1988 | |
| 4,882,155 Confectionery delivery system for antiarrhythmics | 13 | 1988 | |
| 4,882,156 Confectionery delivery system for expectorants | 14 | 1988 | |
| 4,882,159 Confectionery delivery system for appetite suppressants | 16 | 1988 | |
| 5,167,964 Semi-enteric drug delivery systems and methods for preparing same | 65 | 1992 | |
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| 4,801,460 Preparation of solid pharmaceutical forms | 109 | 1987 | |
| 4,880,585 Continuous method of tableting | 67 | 1988 | |
| 4,957,681 Preparation of pharmaceutical mixtures | 65 | 1989 | |
| 5,073,379 Continuous preparation of solid pharmaceutical forms | 79 | 1989 | |
| 5,552,159 Solid depot drug form | 31 | 1993 | |
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| 4,292,300 Controlled release suppositories | 17 | 1977 | |
| 4,265,875 Controlled release suppositories | 22 | 1979 | |
| 4,406,883 Controlled release suppositories consisting essentially of a linear polymer particularly, polyvinyl pyrrolidones | 11 | 1981 | |
| 4,421,736 Sustained release diethylpropion compositions | 53 | 1982 | |
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| 4,828,836 Controlled release pharmaceutical composition | 127 | 1987 | |
| 4,990,341 Controlled release hydromorphone composition | 84 | 1989 | |
| 5,266,331 Controlled release oxycodone compositions | 92 | 1991 | |
| 5,478,577 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level | 82 | 1993 | |
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| 5,013,306 Anti-infective and antithrombogenic medical articles and method for their preparation | 78 | 1990 | |
| 5,165,952 Anti-infective and antithrombogenic medical articles and method for their preparation | 94 | 1990 | |
| 5,451,424 Anti-infective and antithrombogenic medical articles and method for their preparation | 69 | 1992 | |
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| 5,202,128 Sustained release pharmaceutical composition | 111 | 1990 | |
| 5,330,766 Sustained release pharmaceutical composition | 74 | 1993 | |
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| 4,994,227 Method for the preparation of sustained released bolus formulation | 16 | 1989 | |
| 5,283,065 Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form | 67 | 1992 | |
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| 5,262,172 Compositions of gastric acid-resistant microspheres containing buffered bile acids | 26 | 1992 | |
| 5,234,697 Compositions of gastric acid-resistant microspheres containing salts of bile acids | 18 | 1992 | |
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| 4,967,486 Microwave assisted fluidized bed processor | 32 | 1989 | |
| 5,132,142 Apparatus and method for producing pellets by layering power onto particles | 44 | 1991 | |
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| 4,861,598 Controlled release bases for pharmaceuticals | 96 | 1986 | |
| 4,970,075 Controlled release bases for pharmaceuticals | 75 | 1989 | |
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| 5,453,283 Orally administered solvent-free pharmaceutical preparation with delayed active-substance release, and a method of preparing the preparation | 20 | 1993 | |
| 5,472,710 Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture | 43 | 1994 | |
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| 4,764,378 Buccal drug dosage form | 104 | 1986 | |
| 4,806,337 Erodible matrix for sustained release bioactive composition | 87 | 1986 | |
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| 4,343,789 Sustained release pharmaceutical composition of solid medical material | 72 | 1980 | |
| 4,380,534 Solid drug preparations | 40 | 1981 | |
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| 5,378,462 Pancreatin micropellets prepared with polyethylene glycol 4000, paraffin and a lower alcohol by extrusion and rounding | 27 | 1993 | |
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| 4,613,619 Anti-arrhythmic amino-alcohols | 19 | 1985 | |
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| 5,300,300 Controlled release gastroresistant pharmaceutical formulations for oral administration containing bile acids and their salts | 28 | 1992 | |
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| 4,346,709 Drug delivery devices comprising erodible polymer and erosion rate modifier | 93 | 1980 | |
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| 5,055,307 Slow release drug delivery granules and process for production thereof | 34 | 1989 | |
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| 5,356,635 Carbohydrate glass matrix for the sustained release of a therapeutic agent | 40 | 1993 | |
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| 4,894,234 Novel drug delivery system for antiarrhythmics | 65 | 1988 | |
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| 4,310,483 Thermal tumbling granulation | 34 | 1979 | |
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| 5,007,790 Sustained-release oral drug dosage form | 130 | 1989 | |
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| 4,992,100 Gelatine granules as well as methods and apparatus for their manufacture | 20 | 1989 | |
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| 5,133,974 Extended release pharmaceutical formulations | 198 | 1990 | |
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| 4,720,384 Manufacture of hollow fine tubular drug delivery systems | 49 | 1986 | |
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| 5,169,645 Directly compressible granules having improved flow properties | 81 | 1989 | |
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| 5,049,394 Pharmaceutical composition containing high drug load and method for preparing same | 37 | 1989 | |
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| 4,917,899 Controlled absorption diltiazem formulation | 52 | 1987 | |
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| 4,649,042 Rumen delivery device | 11 | 1985 | |
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| 4,880,830 Slow release formulation | 45 | 1987 | |
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| 4,844,907 Pharmaceutical composition comprising analgesic and anti-inflammatory agent | 97 | 1986 | |
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| 4,844,909 Controlled release hydromorphone composition | 78 | 1987 | |
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| 5,196,203 Theophylline dosage form | 37 | 1991 | |
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| 4,389,393 Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose | 206 | 1982 | |
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| 5,567,439 Delivery of controlled-release systems(s) | 71 | 1994 | |
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| 5,240,400 Screw-type extrusion granulating apparatus, especially for producing very fine granules | 16 | 1992 | |
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| 5,178,868 Dosage form | 51 | 1991 | |
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| 4,230,687 Encapsulation of active agents as microdispersions in homogeneous natural polymeric matrices | 135 | 1978 | |
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| 4,935,246 Process for the coating of granules | 99 | 1988 | |
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| 4,818,450 Apparatus and method for forming pellets | 11 | 1986 | |
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| 4,329,794 Ripping attachment for dragline | 28 | 1980 | |
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| 4,842,761 Compositions and methods for controlled release of fragrance-bearing substances | 49 | 1988 | |
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| 5,510,114 Slow release pharmaceutical composition containing a bile acid as an active ingredient | 14 | 1994 | |
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| 5,516,205 Twin extruder | 13 | 1995 | |
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| RE33093 Bioadhesive extruded film for intra-oral drug delivery and process | 109 | 1988 | |
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| 5,102,668 Sustained release pharmaceutical preparation using diffusion barriers whose permeabilities change in response to changing pH | 41 | 1990 | |
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| 5,380,535 Chewable drug-delivery compositions and methods for preparing the same | 48 | 1992 | |
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| 5,350,584 Spheronization process using charged resins | 27 | 1992 | |
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| 5,354,856 Crystalline mixture solid containing maltitol and a process for preparing it | 12 | 1992 | |
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| 4,621,114 Propylene resin composition | 33 | 1984 | |
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| 5,456,923 Method of manufacturing solid dispersion | 88 | 1993 | |
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| 5,030,400 Process and an apparatus for agglomeration of a powdery material | 57 | 1990 | |
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| 5,403,593 Melt granulated compositions for preparing sustained release dosage forms | 29 | 1992 | |
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| 5,395,626 Multilayered controlled release pharmaceutical dosage form | 88 | 1994 | |
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| 4,925,675 Erythromycin microencapsulated granules | 28 | 1988 | |
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| 4,959,208 Active agent delivery device | 26 | 1988 | |
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| 4,834,984 Controlled release dihydrocodeine composition | 73 | 1987 | |
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| 5,271,934 Encapsulated antiperspirant salts and deodorant/antiperspirants | 75 | 1992 | |
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| 5,290,560 Extrusion of an admixture of a meltable binder and a food or drug | 14 | 1991 | |
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| 5,273,758 Directly compressible polyethylene oxide vehicle for preparing therapeutic dosage forms | 41 | 1992 | |
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| 4,533,562 Method of preparing coated solid preparations | 47 | 1984 | |
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| 5,204,119 External preparation comprising calcium silicate | 33 | 1991 | |
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| 5,162,117 Controlled release flutamide composition | 50 | 1991 | |
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| 5,296,266 Method of preparing microcapsule | 19 | 1991 | |
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| 5,023,089 Sustained-release preparations and the process thereof | 44 | 1989 | |
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| 5,257,315 Hearing aid to be worn in the ear | 20 | 1992 | |
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| 5,292,461 Process for the production of pellets | 46 | 1991 | |
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| 5,443,846 Granulated preparations and method of producing the same | 19 | 1994 | |
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| 5,026,560 Spherical granules having core and their production | 96 | 1988 | |
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| 5,035,509 Multi-channel extrusion screw with a zig-zag undercut barrier | 28 | 1990 | |
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| 5,126,145 Controlled release tablet containing water soluble medicament | 96 | 1990 | |
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| 4,801,458 Sustained release pharmaceutical plaster | 89 | 1987 | |
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| 5,476,528 System for improving material release profiles | 14 | 1993 | |
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| 5,340,581 Sustained-release matrices for dental application | 90 | 1992 | |
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| 4,987,136 Method for controlling gastrointestinal dysmotility | 80 | 1986 | |
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| 5,183,690 Starch encapsulation of biologically active agents by a continuous process | 63 | 1990 | |
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| 4,366,172 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use | 28 | 1977 | |
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| 4,344,431 Polymeric article for dispensing drugs | 29 | 1980 | |
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| 5,229,148 Method of combining active ingredients with polyvinyl acetates | 42 | 1992 | |
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| 4,259,314 Method and composition for the preparation of controlled long-acting pharmaceuticals | 107 | 1979 | |
| 4,374,082 Method for making a pharmaceutical and/or nutritional dosage form | 25 | 1981 | |
| 4,882,167 Dry direct compression compositions for controlled release dosage forms | 62 | 1987 | |
| 4,882,152 Confectionery delivery system for laxatives, vitamins and antacids | 50 | 1988 | |
| 4,882,157 Confectionery delivery system for anti-cholesterolemics | 18 | 1988 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jul 1, 2013 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |