Nucleosidic and non-nucleosidic folate conjugates

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United States of America Patent

PATENT NO 6335434
SERIAL NO

09275505

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Abstract

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Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2'-, 3'-, 5'-, nucleobase and internucleotide linkage sites. The folate can be attached via the .alpha.- or .gamma.-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are diclosed. Also disclosed are nucleosidic and non-nucleosidic linkers conjugated to folic acid and related folates.

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Patent Owner(s)

Patent OwnerAddress
ISIS PHARMACEUTICALS INC1896 RUTHERFORD ROAD CARLSBAD CA 92008

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bhat, Balkrishen Carlsbad, CA 172 7018
Cook, Phillip Dan Fallbrook, CA 180 10706
Guzaev, Andrei P Carlsbad, CA 26 674
Manoharan, Muthiah Carlsbad, CA 474 17028

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