Peptide-lipid conjugates, liposomes and lipsomal drug delivery
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United States of America Patent
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Jan 15, 2002
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app pub date -
Jun 29, 1999
filing date -
Oct 15, 1996
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Abstract
Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e.g., tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.
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