Compositions and methods for preventing restenosis following revascularization procedures
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United States of America Patent
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Jan 15, 2002
Grant Date -
Jul 26, 2001
app pub date -
Feb 15, 2001
filing date -
Jun 18, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
In the present invention, a method is provided which reduces or prevents restenosis following revascularization procedures. It has now been found that selective stimulation of adenosine A.sub.2A receptors can reduce or prevent such restenosis. This method may be achieved either by: (a) the administration of selective adenosine A.sub.2A receptor agonists, (b) the administration of a selective adenosine A.sub.1 antagonist in combination with either a selective adenosine A.sub.2A receptor agonist or a non-selective adenosine agonist, or (c) the administration of a selective adenosine A.sub.1 antagonist in order to block adenosine A.sub.1 receptor activation by endogenously-released adenosine. The present invention is also directed to an improved surgical procedure that relies upon selective stimulation of adenosine A.sub.2A receptors.
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