Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals
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United States of America Patent
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Jan 22, 2002
Grant Date -
N/A
app pub date -
Dec 30, 1999
filing date -
Dec 30, 1999
priority date (Note) -
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Abstract
A method for producing a delivery system for transporting pharmaceuticals and other ingredients in a chewable and palatable form is provided. The delivery system comprises a lipid source in which drug actives are homogeneously suspended to form a high solids suspension which can be solidified and molded into an oral dosage form. The lipid source provides an external phase comprising the carrier for the suspension and also provides a hydrophobic film which continuously coats the hydrophilic drug actives and other ingredients. The suspension exhibits pseudoplastic and thixotropic properties which enable it to suspend a large volume of particles relative to the lipid source. The drug particles may be pre-encapsulated before mixing in with the suspension, which provides taste-masking and controlled release qualities to the products formed from the delivery system.
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