Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors
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United States of America Patent
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Jan 22, 2002
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N/A
app pub date -
Jan 27, 2000
filing date -
Jan 27, 1999
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Expired
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Abstract
Compounds of the formula ##STR1## are useful in treating disease conditions mediated by TNF-.alpha., such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
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