US Patent No: 6,341,236

Number of patents in Portfolio can not be more than 2000

Vagal nerve stimulation techniques for treatment of epileptic seizures

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Abstract

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A system and method for using electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus nerve, and a sensor for sensing characteristics of the heart such as a heart rate. The heart rate information from the sensor can be used to determine whether the vagus nerve stimulation is adversely affecting the heart. Once threshold parameters are met, the vagus nerve stimulation may be stopped or adjusted. In an alternative embodiment, a modified pacemaker is used to maintain the heart in desired conditions during the vagus nerve stimulation. In yet another embodiment, a modified pacemaker having circuitry that determines whether a vagus nerve is being stimulated is used. In the event that the vagus nerve is being stimulated, the modified pacemaker may control the heart to maintain it within desired conditions during the vagus nerve stimulation.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
FLINT HILLS SCIENTIFIC, LLCLAWRENCE, KS42

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Frei, Mark G Lawrence, KS 84 2690
Osorio, Ivan Leawood, KS 159 3927

Cited Art Landscape

Patent Info (Count) # Cites Year
 
MEDTRONIC, INC. (4)
5,052,388 Method and apparatus for implementing activity sensing in a pulse generator 245 1989
5,330,508 Apparatus for detection and treatment of tachycardia and fibrillation 63 1993
5,562,711 Method and apparatus for rate-responsive cardiac pacing 164 1994
5,713,923 Techniques for treating epilepsy by brain stimulation and drug infusion 212 1996
 
CIT GROUP/BUSINESS CREDIT, INC. (3)
4,702,254 Neurocybernetic prosthesis 393 1985
4,867,164 Neurocybernetic prosthesis 362 1987
5,025,807 Neurocybernetic prosthesis 319 1989
 
CASE WESTERN RESERVE UNIVERSITY (2)
4,628,942 Asymmetric shielded two electrode cuff 163 1984
4,649,936 Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking 180 1984
 
CYBERONICS, INC. (1)
5,928,272 Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity 338 1998
 
UNIVERSITY OF KANSAS (1)
5,995,868 System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject 312 1997

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
MEDTRONIC, INC. (85)
8,594,798 Multi-modal operation of a medical device system 0 2003
8,579,786 Screening techniques for management of a nervous system disorder 0 2003
8,543,214 Configuring and testing treatment therapy parameters for a medical device system 0 2003
8,187,181 Scoring of sensed neurological signals for use with a medical device system 2 2003
7,715,919 Control of treatment therapy during start-up and during operation of a medical device system 4 2003
7,282,030 Timed delay for redelivery of treatment therapy for a medical device system 29 2003
7,280,867 Clustering of recorded patient neurological activity to determine length of a neurological event 31 2003
7,242,983 Channel-selective blanking for a medical device system 110 2003
7,149,572 Phase shifting of neurological signals in a medical device system 27 2003
7,146,211 Signal quality monitoring and control for a medical device system 48 2003
7,079,977 Synchronization and calibration of clocks for a medical device and calibrated clock 65 2003
8,396,565 Automatic therapy adjustments 0 2003
8,694,115 Therapy programming guidance based on stored programming history 0 2005
8,041,418 System and method for regulating cardiac triggered therapy to the brain 0 2005
8,041,419 System and method for monitoring or treating nervous system disorders 1 2005
7,949,391 System and method for regulating cardiac triggered therapy to the brain 0 2005
7,949,392 System and method for monitoring or treating nervous system disorders 0 2005
7,945,316 System and method for monitoring or treating nervous system disorders 1 2005
7,865,244 System and method for regulating cardiopulmonary triggered therapy to the brain 6 2005
7,787,944 System and method for regulating cardiac triggered therapy to the brain 0 2005
7,684,855 System and method for regulating cardiac triggered therapy to the brain 0 2005
7,680,539 System and method for regulating cardiopulmonary triggered therapy to the brain 0 2005
7,624,293 Synchronization and calibration of clocks for a medical device and calibrated clock 9 2006
7,321,837 Synchronization and calibration of clocks for a medical device and calibrated clock 26 2006
7,819,909 Therapy programming guidance based on stored programming history 0 2006
8,108,038 System and method for segmenting a cardiac signal based on brain activity 3 2006
8,326,431 Implantable medical device for the concurrent treatment of a plurality of neurological disorders and method therefore 0 2006
7,853,322 Closed-loop therapy adjustment 5 2006
7,976,465 Phase shifting of neurological signals in a medical device system 1 2006
7,917,206 Signal quality monitoring and control for a medical device system 4 2006
8,190,251 Method and apparatus for the treatment of movement disorders 1 2006
7,957,797 Closed-loop therapy adjustment 5 2006
7,957,809 Closed-loop therapy adjustment 12 2006
8,165,683 Method and apparatus for detection of nervous system disorders 0 2006
7,764,989 Method and apparatus for detection of nervous system disorders 4 2006
7,761,145 Method and apparatus for detection of nervous system disorders 6 2006
7,761,146 Method and apparatus for detection of nervous system disorders 5 2006
7,979,130 Method and apparatus for detection of nervous system disorders 0 2007
8,485,979 System and method for monitoring or treating nervous system disorders 0 2007
8,214,035 System and method for utilizing brain state information to modulate cardiac therapy 0 2007
8,209,009 System and method for segmenting a cardiac signal based on brain stimulation 1 2007
8,209,019 System and method for utilizing brain state information to modulate cardiac therapy 1 2007
8,112,153 System and method for monitoring or treating nervous system disorders 1 2007
8,068,911 System and method for regulating cardiopulmonary triggered therapy to the brain 0 2007
8,000,788 Implantable medical device for treating neurological conditions including ECG sensing 0 2007
8,112,148 System and method for monitoring cardiac signal activity in patients with nervous system disorders 1 2007
8,108,046 System and method for using cardiac events to trigger therapy for treating nervous system disorders 1 2007
8,738,136 Clustering of recorded patient neurological activity to determine length of a neurological event 0 2007
7,933,646 Clustering of recorded patient neurological activity to determine length of a neurological event 3 2007
8,755,901 Patient assignment of therapy parameter to posture state 0 2009
8,751,011 Defining therapy parameter values for posture states 0 2009
8,708,934 Reorientation of patient posture states for posture-responsive therapy 0 2009
8,688,225 Posture state detection using selectable system control parameters 0 2009
8,644,945 Patient interaction with posture-responsive therapy 0 2009
8,583,252 Patient interaction with posture-responsive therapy 0 2009
8,515,549 Associating therapy adjustments with intended patient posture states 0 2009
8,515,550 Assignment of therapy parameter to multiple posture states 1 2009
8,447,411 Patient interaction with posture-responsive therapy 0 2009
8,437,861 Posture state redefinition based on posture data and therapy adjustments 0 2009
8,401,666 Modification profiles for posture-responsive therapy 3 2009
8,332,041 Patient interaction with posture-responsive therapy 1 2009
8,323,218 Generation of proportional posture information over multiple time intervals 4 2009
8,326,420 Associating therapy adjustments with posture states using stability timers 0 2009
8,315,710 Associating therapy adjustments with patient posture states 0 2009
8,282,580 Data rejection for posture state analysis 2 2009
8,249,718 Programming posture state-responsive therapy with nominal therapy parameters 0 2009
8,231,555 Therapy system including multiple posture sensors 2 2009
8,231,556 Obtaining baseline patient information 0 2009
8,219,206 Dwell time adjustments for posture state-responsive therapy 3 2009
8,209,028 Objectification of posture state-responsive therapy based on patient therapy adjustments 17 2009
8,200,340 Guided programming for posture-state responsive therapy 3 2009
8,175,720 Posture-responsive therapy control based on patient input 0 2009
8,150,531 Associating therapy adjustments with patient posture states 1 2009
8,280,517 Automatic validation techniques for validating operation of medical devices 0 2009
8,068,903 Method and apparatus for detection of nervous system disorders 0 2010
8,792,986 Treatment of the autonomic nervous system 0 2010
8,758,274 Automated adjustment of posture state definitions for a medical device 0 2010
8,388,555 Posture state classification for a medical device 0 2010
8,761,868 Method for monitoring or treating nervous system disorders 0 2010
8,744,562 Method for monitoring or treating nervous system disorders 0 2010
8,579,834 Display of detected patient posture state 1 2011
8,731,656 Closed-loop therapy adjustment 0 2011
8,527,039 Method and apparatus for detection of nervous system disorders 0 2011
8,504,150 Associating therapy adjustments with posture states using a stability timer 0 2012
8,504,161 Modulate vagal signals to reduce inflammation 0 2012
 
CYBERONICS, INC. (69)
7,209,787 Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease 128 2003
7,242,984 Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease 73 2004
7,277,758 Methods and systems for predicting future symptomatology in a patient suffering from a neurological or psychiatric disorder 70 2004
7,324,851 Closed-loop feedback-driven neuromodulation 67 2004
7,231,254 Closed-loop feedback-driven neuromodulation 138 2004
7,751,891 Power supply monitoring for an implantable device 10 2004
7,366,571 Neurostimulator with activation based on changes in body temperature 21 2004
8,600,521 Implantable medical device having multiple electrode/sensor capability and stimulation based on sensed intrinsic activity 0 2005
7,561,918 Autocapture in a neurostimulator 11 2005
7,454,245 Trained and adaptive response in a neurostimulator 18 2005
8,700,163 Cranial nerve stimulation for treatment of substance addiction 0 2005
7,403,820 Closed-loop feedback-driven neuromodulation 71 2005
8,762,065 Closed-loop feedback-driven neuromodulation 0 2005
7,840,280 Cranial nerve stimulation to treat a vocal cord disorder 2 2005
8,660,647 Stimulating cranial nerve to treat pulmonary disorder 0 2005
7,706,874 Stimulating cranial nerve to treat disorders associated with the thyroid gland 0 2005
7,499,752 Selective nerve stimulation for the treatment of eating disorders 3 2005
7,747,325 Systems and methods for monitoring a patient's neurological disease state 9 2005
7,489,561 Implantable medical device with reconfigurable non-volatile program 4 2005
7,620,455 Cranial nerve stimulation to treat eating disorders 15 2005
8,428,731 Sequenced therapy protocols for an implantable medical device 0 2005
8,694,118 Variable output ramping for an implantable medical device 0 2005
7,957,796 Using physiological sensor data with an implantable medical device 0 2005
7,555,344 Selective neurostimulation for treating epilepsy 3 2005
8,725,243 Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders 0 2005
7,643,881 Neurostimulation with activation based on changes in body temperature 0 2006
7,996,079 Input response override for an implantable medical device 0 2006
7,974,697 Medical imaging feedback for an implantable medical device 3 2006
7,657,310 Treatment of reproductive endocrine disorders by vagus nerve stimulation 3 2006
7,801,601 Controlling neuromodulation using stimulus modalities 19 2006
8,180,462 Heat dissipation for a lead assembly 0 2006
7,962,220 Compensation reduction in tissue stimulation therapy 6 2006
7,869,885 Threshold optimization for tissue stimulation therapy 18 2006
8,478,420 Implantable medical device charge balance assessment 0 2006
7,869,867 Implantable neurostimulator with refractory stimulation 0 2006
7,853,329 Monitoring efficacy of neural modulation therapy 14 2006
7,706,875 Modulation of drug effects by vagus nerve stimulation 2 2007
7,974,707 Electrode assembly with fibers for a medical device 4 2007
7,904,175 Trans-esophageal vagus nerve stimulation 8 2007
7,869,884 Non-surgical device and methods for trans-esophageal vagus nerve stimulation 1 2007
7,974,701 Dosing limitation for an implantable medical device 4 2007
7,930,035 Providing output indicative of subject's disease state 6 2007
7,623,928 Controlling a subject's susceptibility to a seizure 7 2007
7,676,263 Minimally invasive system for selecting patient-specific therapy parameters 19 2007
7,962,214 Non-surgical device and methods for trans-esophageal vagus nerve stimulation 4 2007
8,565,867 Changeable electrode polarity stimulation by an implantable medical device 0 2008
8,260,426 Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device 6 2008
8,036,736 Implantable systems and methods for identifying a contra-ictal condition in a subject 10 2008
8,204,603 Blocking exogenous action potentials by an implantable medical device 0 2008
8,457,747 Neurostimulation with signal duration determined by a cardiac cycle 0 2008
8,239,028 Use of cardiac parameters in methods and systems for treating a chronic medical condition 0 2009
8,588,933 Medical lead termination sleeve for implantable medical devices 0 2010
8,560,070 Power supply monitoring for an implantable device 0 2010
8,483,846 Multi-electrode assembly for an implantable medical device 0 2010
8,478,428 Helical electrode for nerve stimulation 0 2010
8,827,912 Methods and systems for detecting epileptic events using NNXX, optionally with nonlinear analysis parameters 0 2010
8,831,732 Method, apparatus and system for validating and quantifying cardiac beat data quality 0 2010
8,649,871 Validity test adaptive constraint modification for cardiac data used for detection of state changes 0 2010
8,781,597 Systems for monitoring a patient's neurological disease state 0 2010
8,786,624 Processing for multi-channel signals 0 2010
8,565,881 Power supply monitoring for an implantable device 0 2010
8,641,646 Seizure detection using coordinate data 0 2010
8,577,459 System and method for estimating battery capacity 0 2011
8,761,884 Device longevity prediction for a device having variable energy consumption 0 2011
8,725,239 Identifying seizures using heart rate decrease 0 2011
8,761,885 Battery life estimation based on voltage depletion rate 0 2011
8,306,627 Dosing limitation for an implantable medical device 0 2011
8,295,946 Electrode assembly with fibers for a medical device 0 2011
8,543,199 Implantable systems and methods for identifying a contra-ictal condition in a subject 0 2011
 
BIO CONTROL MEDICAL (B.C.M.) LTD. (30)
7,734,355 Treatment of disorders by unidirectional nerve stimulation 24 2002
7,778,703 Selective nerve fiber stimulation for treating heart conditions 24 2002
6,907,295 Electrode assembly for nerve control 138 2002
7,613,516 Pelvic disorder treatment device 19 2002
7,321,793 Vagal stimulation for atrial fibrillation therapy 74 2003
7,778,711 Reduction of heart rate variability by parasympathetic stimulation 17 2003
7,890,185 Treatment of disorders by unidirectional nerve stimulation 11 2003
7,885,711 Vagal stimulation for anti-embolic therapy 9 2004
7,346,398 Electrode assembly for nerve control 55 2004
7,324,853 Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders 20 2004
7,561,922 Construction of electrode assembly for nerve control 19 2004
7,634,317 Techniques for applying, calibrating, and controlling nerve fiber stimulation 19 2005
7,974,693 Techniques for applying, configuring, and coordinating nerve fiber stimulation 11 2005
8,386,056 Parasympathetic stimulation for treating atrial arrhythmia and heart failure 0 2005
7,885,709 Nerve stimulation for treating disorders 11 2005
7,627,384 Techniques for nerve stimulation 11 2005
8,609,082 Administering bone marrow progenitor cells or myoblasts followed by application of an electrical current for cardiac repair, increasing blood supply or enhancing angiogenesis 0 2006
7,844,346 Electrode assembly for nerve control 10 2006
7,904,176 Techniques for reducing pain associated with nerve stimulation 9 2006
8,204,591 Techniques for prevention of atrial fibrillation 0 2007
8,060,197 Parasympathetic stimulation for termination of non-sinus atrial tachycardia 6 2007
8,116,881 Electrode assembly for nerve control 6 2007
8,005,542 Therapeutic maintenance of atrial fibrillation by electrical stimulation 8 2007
8,326,438 Techniques for nerve stimulation 0 2009
8,718,791 Electrode cuffs 0 2010
8,565,896 Electrode cuff with recesses 0 2010
8,571,651 Techniques for reducing pain associated with nerve stimulation 0 2011
8,571,653 Nerve stimulation techniques 1 2011
8,494,655 Electrode devices with resistive elements 1 2011
8,725,271 Electrode device with elongated electrode 0 2013
 
CARDIAC PACEMAKERS, INC. (26)
7,657,312 Multi-site ventricular pacing therapy with parasympathetic stimulation 44 2003
8,126,560 Stimulation lead for stimulating the baroreceptors in the pulmonary artery 6 2003
8,024,050 Lead for stimulating the baroreceptors in the pulmonary artery 14 2003
7,509,166 Automatic baroreflex modulation responsive to adverse event 62 2003
8,200,331 System and method for filtering neural stimulation 3 2004
8,126,559 Neural stimulation with avoidance of inappropriate stimulation 6 2004
7,840,266 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 20 2005
7,660,628 System to provide myocardial and neural stimulation 35 2005
7,881,782 Neural stimulation system to prevent simultaneous energy discharges 8 2005
7,570,999 Implantable device for treating epilepsy and cardiac rhythm disorders 48 2005
8,131,359 System and method to deliver therapy in presence of another therapy 3 2008
8,131,362 Combined neural stimulation and cardiac resynchronization therapy 9 2009
8,200,332 System and method for filtering neural stimulation 2 2009
8,478,397 System to provide myocardial and neural stimulation 0 2010
8,406,876 Closed loop neural stimulation synchronized to cardiac cycles 1 2010
8,571,655 Multi-site ventricular pacing therapy with parasympathetic stimulation 1 2010
8,483,823 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 0 2010
8,548,585 Concurrent therapy detection in implantable medical devices 0 2010
8,831,718 Neural stimulation system to prevent simultaneous energy discharges 0 2011
8,473,076 Lead for stimulating the baroreceptors in the pulmonary artery 1 2011
8,682,434 Neural stimulation with avoidance of inappropriate stimulation 0 2012
8,504,149 System and method to deliver therapy in presence of another therapy 0 2012
8,768,462 System and method for filtering neural stimulation 0 2012
8,660,648 Implantable and rechargeable neural stimulator 0 2012
8,838,239 Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 0 2013
8,805,494 System and method to deliver therapy in presence of another therapy 0 2013
 
NEVRO CORPORATION (24)
8,255,057 Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions 4 2009
8,838,248 Devices for controlling high frequency spinal cord modulation for inhibiting pain, and associated systems and methods, including simplified program selection 0 2010
8,712,533 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2010
8,694,108 Devices for controlling high frequency spinal cord modulation for inhibiting pain, and associated systems and methods, including simplified controllers 0 2010
8,423,147 Devices for controlling high frequency spinal cord modulation for inhibiting pain, and associated systems and methods, including simplified controllers 4 2011
8,209,021 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 4 2011
8,170,675 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 6 2011
8,649,874 Extended pain relief via high frequency spinal cord modulation, and associated systems and methods 0 2011
8,396,559 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 3 2012
8,509,905 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 1 2012
8,428,748 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 3 2012
8,359,102 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 7 2012
8,359,103 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 8 2012
8,355,792 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 7 2012
8,509,906 Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions 0 2012
8,774,926 Multi-frequency neural treatments and associated systems and methods 0 2012
8,768,472 Multi-frequency neural treatments and associated systems and methods 0 2012
8,694,109 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2012
8,660,654 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2012
8,718,781 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2012
8,718,782 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2013
8,676,331 Devices for controlling spinal cord modulation for inhibiting pain, and associated systems and methods, including controllers for automated parameter selection 0 2013
8,554,326 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2013
8,792,988 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2013
 
EnteroMedics Inc. (21)
7,489,969 Vagal down-regulation obesity treatment 23 2003
7,444,183 Intraluminal electrode apparatus and method 52 2004
7,167,750 Obesity treatment with electrically induced vagal down regulation 133 2004
7,844,338 High frequency obesity treatment 15 2004
7,833,279 Pancreatic exocrine secretion diversion apparatus and method 2 2004
7,613,515 High frequency vagal blockage therapy 29 2005
7,822,486 Custom sized neural electrodes 20 2005
7,672,727 Neural electrode treatment 8 2005
7,986,995 Bulimia treatment 6 2007
7,720,540 Pancreatitis treatment 9 2007
7,693,577 Irritable bowel syndrome treatment 9 2007
7,630,769 GI inflammatory disease treatment 12 2007
7,729,771 Nerve stimulation and blocking for treatment of gastrointestinal disorders 11 2007
8,103,349 Neural electrode treatment 6 2009
8,010,204 Nerve blocking for treatment of gastrointestinal disorders 4 2010
8,617,095 Pancreatic exocrine secretion diversion apparatus and method 0 2010
8,046,085 Controlled vagal blockage therapy 8 2010
8,825,164 Neural modulation devices and methods 0 2011
8,369,952 Bulimia treatment 2 2011
8,538,542 Nerve stimulation and blocking for treatment of gastrointestinal disorders 0 2011
8,538,533 Controlled vagal blockage therapy 0 2011
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (20)
7,860,570 Implantable microstimulators and methods for unidirectional propagation of action potentials 50 2002
7,292,890 Vagus nerve stimulation via unidirectional propagation of action potentials 139 2002
7,203,548 Cavernous nerve stimulation via unidirectional propagation of action potentials 64 2002
7,308,303 Thrombolysis and chronic anticoagulation therapy 20 2002
7,167,751 Method of using a fully implantable miniature neurostimulator for vagus nerve stimulation 62 2004
7,627,383 Implantable stimulator 4 2005
7,660,631 Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction 1 2005
7,801,600 Controlling charge flow in the electrical stimulation of tissue 5 2005
8,175,717 Ultracapacitor powered implantable pulse generator with dedicated power supply 3 2005
7,729,758 Magnetically coupled microstimulators 11 2005
7,890,177 Device and therapy for erectile dysfunction and other sexual dysfunction 1 2006
7,865,243 Device and therapy for erectile dysfunction and other sexual dysfunction 1 2006
7,801,602 Controlling stimulation parameters of implanted tissue stimulators 5 2006
7,899,539 Cavernous nerve stimulation via unidirectional propagation of action potentials 9 2006
7,877,136 Enhancement of neural signal transmission through damaged neural tissue via hyperpolarizing electrical stimulation current 29 2007
7,783,362 Vagus nerve stimulation via unidirectional propagation of action potentials 1 2007
7,877,137 Thrombolysis and chronic anticoagulation therapy 0 2007
8,600,512 Methods and systems for treating seizures caused by brain stimulation 0 2008
8,548,604 Implantable microstimulators and methods for unidirectional propagation of action potentials 0 2010
8,712,547 Cavernous nerve stimulation via unidirectional propagation of action potentials 0 2011
 
ELECTROCORE LLC (20)
7,747,324 Electrical stimulation treatment of bronchial constriction 11 2006
7,725,188 Electrical stimulation treatment of hypotension 8 2006
7,711,430 Methods and apparatus for treating anaphylaxis using electrical modulation 10 2006
8,209,034 Methods and apparatus for electrical stimulation treatment using esophageal balloon and electrode 7 2008
8,401,650 Methods and apparatus for electrical treatment using balloon and electrode 5 2009
8,812,112 Electrical treatment of bronchial constriction 0 2009
7,869,879 Electrical stimulation treatment of hypotension 8 2009
8,543,211 Methods and apparatus for deep brain stimulation 0 2009
8,682,449 Methods and apparatus for transcranial stimulation 0 2009
8,041,428 Electrical stimulation treatment of hypotension 9 2009
8,010,197 Methods and apparatus for treating anaphylaxis using electrical modulation 10 2010
8,840,537 Non-invasive treatment of bronchial constriction 0 2011
8,676,330 Electrical and magnetic stimulators used to treat migraine/sinus headache and comorbid disorders 0 2011
8,676,324 Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders 0 2011
8,099,167 Methods and apparatus for treating anaphylaxis using electrical modulation 9 2011
8,233,988 Electrical stimulation treatment of hypotension 9 2011
8,204,598 Methods and apparatus for treating bronchial restriction using electrical modulation 7 2011
8,483,835 Methods and apparatus for treating anaphylaxis using electrical modulation 1 2012
8,612,004 Electrical stimulation treatment of hypotension 0 2012
8,666,496 Methods and apparatus for electrical treatment using balloon and electrode 0 2013
 
FLINT HILLS SCIENTIFIC, LLC (14)
7,389,144 Medical device failure detection and warning system 32 2004
8,515,538 Medical device failure detection and warning system 0 2008
8,417,344 Dynamic cranial nerve stimulation based on brain state determination from cardiac data 0 2008
8,634,922 Vagal nerve stimulation techniques for treatment of epileptic seizures 0 2008
8,562,536 Algorithm for detecting a seizure from cardiac data 0 2010
8,679,009 Systems approach to comorbidity assessment 0 2010
8,571,643 Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex 0 2010
8,452,387 Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex 0 2010
8,337,404 Detecting, quantifying, and/or classifying seizures using multimodal data 0 2010
8,562,523 Detecting, assessing and managing extreme epileptic events 0 2011
8,562,524 Detecting, assessing and managing a risk of death in epilepsy 0 2011
8,382,667 Detecting, quantifying, and/or classifying seizures using multimodal data 0 2011
8,684,921 Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis 0 2012
8,768,471 Dynamic cranial nerve stimulation based on brain state determination from cardiac data 0 2013
 
CVRX, INC. (11)
8,086,314 Devices and methods for cardiovascular reflex control 7 2002
7,840,271 Stimulus regimens for cardiovascular reflex control 37 2005
8,290,595 Method and apparatus for stimulation of baroreceptors in pulmonary artery 2 2006
8,060,206 Baroreflex modulation to gradually decrease blood pressure 9 2006
7,813,812 Baroreflex stimulator with integrated pressure sensor 13 2006
8,838,246 Devices and methods for cardiovascular reflex treatments 0 2006
8,606,359 System and method for sustained baroreflex stimulation 0 2007
7,949,400 Devices and methods for cardiovascular reflex control via coupled electrodes 7 2009
8,583,236 Devices and methods for cardiovascular reflex control 0 2010
8,718,789 Electrode structures and methods for their use in cardiovascular reflex control 0 2010
8,712,531 Automatic baroreflex modulation responsive to adverse event 0 2012
 
HOLAIRA, INC. (10)
8,172,827 Apparatus for treating asthma using neurotoxin 2 2006
8,483,831 System and method for bronchial dilation 1 2009
8,088,127 Systems, assemblies, and methods for treating a bronchial tree 11 2009
8,226,638 Systems, assemblies, and methods for treating a bronchial tree 8 2011
8,821,489 Systems, assemblies, and methods for treating a bronchial tree 0 2012
8,808,280 Systems, assemblies, and methods for treating a bronchial tree 0 2012
8,489,192 System and method for bronchial dilation 2 2012
8,731,672 System and method for bronchial dilation 0 2013
8,777,943 Delivery devices with coolable energy emitting assemblies 0 2013
8,740,895 Delivery devices with coolable energy emitting assemblies 0 2013
 
AMS RESEARCH CORPORATION (7)
6,862,480 Pelvic disorder treatment device 50 2001
8,195,296 Apparatus for treating stress and urge incontinence 12 2006
8,160,710 Systems and methods for implanting tissue stimulation electrodes in the pelvic region 0 2007
8,340,786 Incontinence treatment device 0 2008
8,083,663 Pelvic disorder treatment 7 2009
8,380,312 Multi-zone stimulation implant system and method 0 2010
8,774,942 Tissue anchor 0 2012
 
CATHOLIC HEALTHCARE WEST (6)
8,615,309 Microburst electrical stimulation of cranial nerves for the treatment of medical conditions 0 2007
8,219,188 Synchronization of vagus nerve stimulation with the cardiac cycle of a patient 3 2007
8,150,508 Vagus nerve stimulation method 3 2007
8,738,126 Synchronization of vagus nerve stimulation with the cardiac cycle of a patient 0 2009
8,660,666 Microburst electrical stimulation of cranial nerves for the treatment of medical conditions 0 2009
8,280,505 Vagus nerve stimulation method 2 2009
 
PACESETTER, INC. (5)
7,123,961 Stimulation of autonomic nerves 106 2004
7,676,275 Endovascular lead for chronic nerve stimulation 12 2005
7,869,869 Subcardiac threshold vagal nerve stimulation 6 2006
7,813,805 Subcardiac threshold vagal nerve stimulation 8 2006
8,473,068 Subcardiac threshold vagal nerve stimulation 0 2010
 
BRAINSGATE LTD. (4)
7,561,919 SPG stimulation via the greater palatine canal 6 2006
8,010,189 SPG stimulation for treating complications of subarachnoid hemorrhage 0 2007
7,908,000 Transmucosal electrical stimulation 1 2007
8,406,869 Post-acute electrical stimulation treatment of adverse cerebrovascular events 0 2011
 
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (3)
7,228,167 Method and apparatus for detecting vagus nerve stimulation 26 2004
7,803,195 Obesity treatment and device 14 2005
8,372,158 Obesity treatment and device 0 2010
 
SETPOINT MEDICAL CORPORATION (3)
8,412,338 Devices and methods for optimizing electrode placement for anti-inflamatory stimulation 1 2009
8,612,002 Neural stimulation devices and systems for treatment of chronic inflammation 0 2010
8,788,034 Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation 0 2012
 
SYNECOR LLC (3)
8,116,883 Intravascular device for neuromodulation 2 2007
7,925,352 System and method for transvascularly stimulating contents of the carotid sheath 6 2009
8,369,954 System and method for transvascularly stimulating contents of the carotid sheath 0 2011
 
KWALATA TRADING LIMITED (2)
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Other [Check patent profile for assignment information] (3)
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