US Patent No: 6,341,236

Number of patents in Portfolio can not be more than 2000

Vagal nerve stimulation techniques for treatment of epileptic seizures

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A system and method for using electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus nerve, and a sensor for sensing characteristics of the heart such as a heart rate. The heart rate information from the sensor can be used to determine whether the vagus nerve stimulation is adversely affecting the heart. Once threshold parameters are met, the vagus nerve stimulation may be stopped or adjusted. In an alternative embodiment, a modified pacemaker is used to maintain the heart in desired conditions during the vagus nerve stimulation. In yet another embodiment, a modified pacemaker having circuitry that determines whether a vagus nerve is being stimulated is used. In the event that the vagus nerve is being stimulated, the modified pacemaker may control the heart to maintain it within desired conditions during the vagus nerve stimulation.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
FLINT HILLS SCIENTIFIC, LLCLAWRENCE, KS59

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Frei, Mark G 2513 via Linda Dr., Lawrence, KS 66047 62 4053
Osorio, Ivan 4005 W. 124th St., Leawood, KS 66209 136 5854

Cited Art Landscape

Patent Info (Count) # Cites Year
 
CYBERONICS, INC. (1)
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CIT GROUP/BUSINESS CREDIT, INC., THE (3)
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4,867,164 Neurocybernetic prosthesis 418 1987
5,025,807 Neurocybernetic prosthesis 376 1989
 
CASE WESTERN RESERVE UNIVERSITY (2)
4,628,942 Asymmetric shielded two electrode cuff 200 1984
4,649,936 Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking 293 1984
 
UNIVERSITY OF KANSAS (1)
5,995,868 System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject 360 1997
 
MEDTRONIC, INC. (4)
5,052,388 Method and apparatus for implementing activity sensing in a pulse generator 260 1989
5,330,508 Apparatus for detection and treatment of tachycardia and fibrillation 66 1993
5,562,711 Method and apparatus for rate-responsive cardiac pacing 173 1994
5,713,923 Techniques for treating epilepsy by brain stimulation and drug infusion 233 1996
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (14)
* 6,587,727 Vagal nerve stimulation techniques for treatment of epileptic seizures 214 2001
6,920,357 Vagal nerve stimulation techniques for treatment of epileptic seizures 146 2003
* 2003/0195,574 Vagal nerve stimulation techniques for treatment of epileptic seizures 16 2003
7,499,894 Cerebral programming 12 2003
* 2004/0131,998 Cerebral programming 73 2003
* 2006/0229,685 Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) 15 2006
* 2008/0109,045 SELECTIVE NERVE FIBER STIMULATION FOR TREATING CONDITIONS 14 2007
* 2009/0275,997 VAGUS NERVE STIMULATION ELECTRODES AND METHODS OF USE 38 2009
* 2009/0306,734 COMBINED NEURAL STIMULATION AND CARDIAC RESYNCHRONIZATION THERAPY 5 2009
* 2010/0114,226 SYSTEM TO PROVIDE MYOCARDIAL AND NEURAL STIMULATION 5 2010
* 2010/0125,307 MULTI-SITE VENTRICULAR PACING THERAPY WITH PARASYMPATHETIC STIMULATION 21 2010
* 2010/0331,908 SUBCARDIAC THRESHOLD VAGAL NERVE STIMULATION 13 2010
* 2011/0082,537 TRANSVASCULAR NEURAL STIMULATION DEVICE 6 2010
* 2011/0112,592 NEURAL STIMULATION SYSTEM TO PREVENT SIMULTANEOUS ENERGY DISCHARGES 2 2011
 
CYBERONICS, INC. (127)
7,209,787 Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease 197 2003
* 2005/0021,103 Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease 94 2003
7,242,984 Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease 123 2004
7,277,758 Methods and systems for predicting future symptomatology in a patient suffering from a neurological or psychiatric disorder 100 2004
* 2005/0021,104 Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease 82 2004
7,324,851 Closed-loop feedback-driven neuromodulation 111 2004
7,231,254 Closed-loop feedback-driven neuromodulation 208 2004
* 7,751,891 Power supply monitoring for an implantable device 22 2004
7,366,571 Neurostimulator with activation based on changes in body temperature 28 2004
* 2006/0129,202 Neurostimulator with activation based on changes in body temperature 14 2004
8,600,521 Implantable medical device having multiple electrode/sensor capability and stimulation based on sensed intrinsic activity 3 2005
* 2006/0167,497 Implantable medical device having multiple electrode/sensor capability and stimulation based on sensed intrinsic activity 119 2005
7,561,918 Autocapture in a neurostimulator 20 2005
7,454,245 Trained and adaptive response in a neurostimulator 29 2005
* 2006/0173,493 Multi-phasic signal for stimulation by an implantable device 112 2005
7,403,820 Closed-loop feedback-driven neuromodulation 96 2005
* 2005/0222,626 Cloosed-loop feedback-driven neuromodulation 24 2005
8,762,065 Closed-loop feedback-driven neuromodulation 0 2005
* 2006/0293,720 Closed-loop feedback-driven neuromodulation 158 2005
7,840,280 Cranial nerve stimulation to treat a vocal cord disorder 2 2005
* 2007/0027,482 Cranial nerve stimulation to treat a vocal cord disorder 33 2005
8,660,647 Stimulating cranial nerve to treat pulmonary disorder 0 2005
7,706,874 Stimulating cranial nerve to treat disorders associated with the thyroid gland 0 2005
7,499,752 Selective nerve stimulation for the treatment of eating disorders 7 2005
* 2007/0027,498 Selective nerve stimulation for the treatment of eating disorders 62 2005
* 2007/0027,499 Neurostimulation device for treating mood disorders 14 2005
* 2007/0027,486 Medical devices for enhancing intrinsic neural activity 78 2005
* 2007/0025,608 Enhancing intrinsic neural activity using a medical device to treat a patient 18 2005
7,747,325 Systems and methods for monitoring a patient's neurological disease state 36 2005
* 2007/0142,862 Systems and methods for monitoring a patient's neurological disease state 89 2005
7,489,561 Implantable medical device with reconfigurable non-volatile program 13 2005
7,620,455 Cranial nerve stimulation to treat eating disorders 24 2005
8,428,731 Sequenced therapy protocols for an implantable medical device 0 2005
8,694,118 Variable output ramping for an implantable medical device 0 2005
7,957,796 Using physiological sensor data with an implantable medical device 0 2005
7,555,344 Selective neurostimulation for treating epilepsy 11 2005
* 2007/0100,392 Selective neurostimulation for treating epilepsy 90 2005
9,042,988 Closed-loop vagus nerve stimulation 0 2005
8,868,172 Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders 0 2005
8,725,243 Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders 1 2005
* 2007/0150,024 Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders 93 2005
* 2007/0150,025 Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders 94 2005
7,643,881 Neurostimulation with activation based on changes in body temperature 0 2006
7,996,079 Input response override for an implantable medical device 0 2006
7,974,697 Medical imaging feedback for an implantable medical device 6 2006
7,657,310 Treatment of reproductive endocrine disorders by vagus nerve stimulation 6 2006
7,801,601 Controlling neuromodulation using stimulus modalities 38 2006
8,180,462 Heat dissipation for a lead assembly 2 2006
* 2007/0244,535 Heat dissipation for a lead assembly 5 2006
7,962,220 Compensation reduction in tissue stimulation therapy 15 2006
7,869,885 Threshold optimization for tissue stimulation therapy 38 2006
8,478,420 Implantable medical device charge balance assessment 0 2006
* 2008/0015,641 Implantable Medical Device Charge Balance Assessment 8 2006
7,869,867 Implantable neurostimulator with refractory stimulation 0 2006
9,320,900 Methods and systems for determining subject-specific parameters for a neuromodulation therapy 0 2006
9,113,801 Methods and systems for continuous EEG monitoring 0 2006
7,853,329 Monitoring efficacy of neural modulation therapy 19 2006
* 2007/0167,991 Methods and systems for determining subject-specific parameters for a neuromodulation therapy 94 2006
* 2007/0161,919 Methods and systems for continuous EEG monitoring 109 2006
7,706,875 Modulation of drug effects by vagus nerve stimulation 4 2007
7,974,707 Electrode assembly with fibers for a medical device 11 2007
* 2007/0287,931 Methods and systems for administering an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders 43 2007
7,904,175 Trans-esophageal vagus nerve stimulation 18 2007
7,869,884 Non-surgical device and methods for trans-esophageal vagus nerve stimulation 2 2007
7,974,701 Dosing limitation for an implantable medical device 11 2007
* 2008/0269,839 Dosing Limitation for an Implantable Medical Device 1 2007
7,930,035 Providing output indicative of subject's disease state 14 2007
7,623,928 Controlling a subject's susceptibility to a seizure 14 2007
* 2007/0208,212 Controlling a Subject's Susceptibility to a Seizure 66 2007
7,676,263 Minimally invasive system for selecting patient-specific therapy parameters 31 2007
* 2008/0027,348 Minimally Invasive Monitoring Systems for Monitoring a Patient's Propensity for a Neurological Event 35 2007
* 2008/0021,341 Methods and Systems for Facilitating Clinical Trials 37 2007
7,962,214 Non-surgical device and methods for trans-esophageal vagus nerve stimulation 10 2007
8,942,798 Alternative operation mode for an implantable medical device based upon lead condition 1 2007
8,868,203 Dynamic lead condition detection for an implantable medical device 0 2007
8,565,867 Changeable electrode polarity stimulation by an implantable medical device 0 2008
8,260,426 Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device 12 2008
* 2009/0192,564 Changeable electrode polarity stimulation by an implantable medical device 3 2008
* 2008/0208,074 Methods and Systems for Characterizing and Generating a Patient-Specific Seizure Advisory System 32 2008
8,036,736 Implantable systems and methods for identifying a contra-ictal condition in a subject 21 2008
8,204,603 Blocking exogenous action potentials by an implantable medical device 0 2008
8,457,747 Neurostimulation with signal duration determined by a cardiac cycle 2 2008
9,259,591 Housing for an implantable medical device 0 2008
* 2009/0171,168 Systems and Method for Recording Clinical Manifestations of a Seizure 7 2008
* 2009/0171,420 Housing for an Implantable Medical Device 16 2008
8,239,028 Use of cardiac parameters in methods and systems for treating a chronic medical condition 1 2009
* 2010/0274,308 USE OF CARDIAC PARAMETERS IN METHODS AND SYSTEMS FOR TREATING A CHRONIC MEDICAL CONDITION 0 2009
* 2010/0168,603 BRAIN STATE ANALYSIS BASED ON SELECT SEIZURE ONSET CHARACTERISTICS AND CLINICAL MANIFESTATIONS 8 2009
8,849,390 Processing for multi-channel signals 0 2009
8,588,933 Medical lead termination sleeve for implantable medical devices 1 2010
* 2010/0179,627 Medical Lead Termination Sleeve for Implantable Medical Devices 7 2010
* 2011/0218,820 Displaying and Manipulating Brain Function Data Including Filtering of Annotations 6 2010
* 2011/0219,325 Displaying and Manipulating Brain Function Data Including Enhanced Data Scrolling Functionality 9 2010
8,560,070 Power supply monitoring for an implantable device 0 2010
* 2010/0198,313 POWER SUPPLY MONITORING FOR AN IMPLANTABLE DEVICE 0 2010
8,483,846 Multi-electrode assembly for an implantable medical device 0 2010
* 2010/0192,374 Multi-Electrode Assembly for an Implantable Medical Device 0 2010
8,478,428 Helical electrode for nerve stimulation 0 2010
8,827,912 Methods and systems for detecting epileptic events using NNXX, optionally with nonlinear analysis parameters 0 2010
8,831,732 Method, apparatus and system for validating and quantifying cardiac beat data quality 0 2010
8,649,871 Validity test adaptive constraint modification for cardiac data used for detection of state changes 1 2010
8,781,597 Systems for monitoring a patient's neurological disease state 0 2010
* 2010/0217,348 Systems for Monitoring a Patient's Neurological Disease State 8 2010
8,786,624 Processing for multi-channel signals 0 2010
8,565,881 Power supply monitoring for an implantable device 0 2010
8,641,646 Seizure detection using coordinate data 0 2010
8,577,459 System and method for estimating battery capacity 0 2011
* 2011/0166,430 SYSTEM AND METHODS FOR ANALYZING SEIZURE ACTIVITY 10 2011
8,972,013 Using physiological sensor data with an implantable medical device 0 2011
* 2011/0172,732 USING PHYSIOLOGICAL SENSOR DATA WITH AN IMPLANTABLE MEDICAL DEVICE 0 2011
8,761,884 Device longevity prediction for a device having variable energy consumption 0 2011
8,725,239 Identifying seizures using heart rate decrease 0 2011
8,761,885 Battery life estimation based on voltage depletion rate 0 2011
8,306,627 Dosing limitation for an implantable medical device 0 2011
8,295,946 Electrode assembly with fibers for a medical device 0 2011
* 2011/0224,767 ELECTRODE ASSEMBLY WITH FIBERS FOR A MEDICAL DEVICE 0 2011
8,543,199 Implantable systems and methods for identifying a contra-ictal condition in a subject 0 2011
8,855,775 Systems and methods of reducing artifact in neurological stimulation systems 2 2012
9,056,195 Optimization of cranial nerve stimulation to treat seizure disorderse during sleep 0 2013
8,874,218 Neurostimulation with signal duration determined by a cardiac cycle 0 2013
9,241,647 Algorithm for detecting a seizure from cardiac data 0 2013
9,289,595 Medical lead termination sleeve for implantable medical devices 0 2013
9,220,910 Seizure detection using coordinate data 0 2014
9,302,109 Cranial nerve stimulation to treat depression during sleep 0 2014
9,044,188 Methods and systems for managing epilepsy and other neurological disorders 0 2014
9,126,054 Device longevity prediction for a device having variable energy consumption 0 2014
9,242,110 Device longevity prediction for a device having variable energy consumption 0 2015
 
Holaira, Inc. (21)
8,172,827 Apparatus for treating asthma using neurotoxin 10 2006
* 2006/0222,667 Apparatus for treating asthma using neurotoxin 23 2006
8,483,831 System and method for bronchial dilation 6 2009
8,088,127 Systems, assemblies, and methods for treating a bronchial tree 60 2009
* 2009/0306,644 SYSTEMS, ASSEMBLIES, AND METHODS FOR TREATING A BRONCHIAL TREE 93 2009
9,149,328 Systems, apparatuses, and methods for treating tissue and controlling stenosis 0 2010
8,911,439 Non-invasive and minimally invasive denervation methods and systems for performing the same 3 2010
9,005,195 Delivery devices with coolable energy emitting assemblies 0 2011
8,932,289 Delivery devices with coolable energy emitting assemblies 1 2011
8,226,638 Systems, assemblies, and methods for treating a bronchial tree 19 2011
8,961,507 Systems, assemblies, and methods for treating a bronchial tree 0 2012
8,961,508 Systems, assemblies, and methods for treating a bronchial tree 0 2012
8,821,489 Systems, assemblies, and methods for treating a bronchial tree 5 2012
8,808,280 Systems, assemblies, and methods for treating a bronchial tree 5 2012
8,489,192 System and method for bronchial dilation 10 2012
9,339,618 Method and apparatus for controlling narrowing of at least one airway 0 2012
8,731,672 System and method for bronchial dilation 4 2013
9,017,324 Delivery devices with coolable energy emitting assemblies 0 2013
8,777,943 Delivery devices with coolable energy emitting assemblies 16 2013
8,740,895 Delivery devices with coolable energy emitting assemblies 16 2013
9,125,643 System and method for bronchial dilation 0 2014
 
OTONOMY, INC. (2)
7,803,148 Flow-induced delivery from a drug mass 1 2007
8,298,176 Flow-induced delivery from a drug mass 0 2010
 
INTERVENTIONAL AUTONOMICS CORPORATION (5)
8,116,883 Intravascular device for neuromodulation 48 2007
* 2007/0255,379 Intravascular device for neuromodulation 64 2007
7,925,352 System and method for transvascularly stimulating contents of the carotid sheath 28 2009
* 2010/0023,088 SYSTEM AND METHOD FOR TRANSVASCULARLY STIMULATING CONTENTS OF THE CAROTID SHEATH 38 2009
8,369,954 System and method for transvascularly stimulating contents of the carotid sheath 1 2011
 
Biocontrol Medical Ltd. (10)
* 2006/0271,115 Vagal stimulation for anti-embolic therapy 59 2004
* 2005/0065,553 Applications of vagal stimulation 167 2004
* 2005/0038,490 Electrode assembly for nerve control 16 2004
* 2005/0102,007 Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders 12 2004
* 2006/0136,024 Construction of electrode assembly for nerve control 33 2004
* 2005/0197,675 Techniques for applying, calibrating, and controlling nerve fiber stimulation 137 2005
* 2008/0065,158 Techniques for reducing pain associated with nerve stimulation 54 2006
* 2007/0179,543 Techniques for prevention of atrial fibrillation 40 2007
* 2007/0203,527 Parasympathetic stimulation for termination of non-sinus atrial tachycardia 24 2007
* 2008/0125,825 Therapeutic maintenance of atrial fibrillation by electrical stimulation 4 2007
 
ELECTROCORE, INC. (7)
* 2007/0106,337 Methods And Apparatus For Treating Disorders Through Neurological And/Or Muscular Intervention 124 2006
* 2009/0157,138 Methods And Apparatus For Treating Ileus Condition Using Electrical Signals 0 2008
* 2010/0160,996 METHODS AND APPARATUS FOR ELECTRICAL STIMULATION TREATMENT USING ESOPHAGEAL BALLOON AND ELECTRODE 18 2008
* 2009/0281,593 Electrical Treatment Of Bronchial Constriction 40 2009
* 2009/0187,231 Electrical Treatment Of Bronchial Constriction 12 2009
* 2010/0241,188 Percutaneous Electrical Treatment Of Tissue 20 2009
* 2009/0292,333 ELECTRICAL STIMULATION TREATMENT OF HYPOTENSION 1 2009
 
DIGNITY HEALTH (2)
9,289,599 Vagus nerve stimulation method 0 2012
9,108,041 Microburst electrical stimulation of cranial nerves for the treatment of medical conditions 0 2013
 
Electrocore, LLC (51)
7,747,324 Electrical stimulation treatment of bronchial constriction 21 2006
7,725,188 Electrical stimulation treatment of hypotension 17 2006
7,711,430 Methods and apparatus for treating anaphylaxis using electrical modulation 21 2006
8,209,034 Methods and apparatus for electrical stimulation treatment using esophageal balloon and electrode 16 2008
8,401,650 Methods and apparatus for electrical treatment using balloon and electrode 12 2009
8,812,112 Electrical treatment of bronchial constriction 0 2009
7,869,879 Electrical stimulation treatment of hypotension 17 2009
8,543,211 Methods and apparatus for deep brain stimulation 0 2009
8,682,449 Methods and apparatus for transcranial stimulation 5 2009
* 2010/0057,178 METHODS AND APPARATUS FOR SPINAL CORD STIMULATION USING EXPANDABLE ELECTRODE 32 2009
8,041,428 Electrical stimulation treatment of hypotension 18 2009
* 2010/0174,340 Methods and Apparatus for Applying Energy to Patients 23 2010
9,037,247 Non-invasive treatment of bronchial constriction 0 2010
8,010,197 Methods and apparatus for treating anaphylaxis using electrical modulation 19 2010
* 2011/0071,592 METHODS AND APPARATUS FOR TREATING ANAPHYLAXIS USING ELECTRICAL MODULATION 1 2010
8,868,177 Non-invasive treatment of neurodegenerative diseases 2 2011
* 2011/0152,967 NON-INVASIVE TREATMENT OF NEURODEGENERATIVE DISEASES 42 2011
8,840,537 Non-invasive treatment of bronchial constriction 1 2011
8,874,205 Device and methods for non-invasive electrical stimulation and their use for vagal nerve stimulation 1 2011
* 2011/0230,938 DEVICE AND METHODS FOR NON-INVASIVE ELECTRICAL STIMULATION AND THEIR USE FOR VAGAL NERVE STIMULATION 26 2011
8,676,330 Electrical and magnetic stimulators used to treat migraine/sinus headache and comorbid disorders 1 2011
* 2011/0230,701 ELECTRICAL AND MAGNETIC STIMULATORS USED TO TREAT MIGRAINE/SINUS HEADACHE AND COMORBID DISORDERS 57 2011
8,676,324 Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders 1 2011
8,099,167 Methods and apparatus for treating anaphylaxis using electrical modulation 18 2011
8,233,988 Electrical stimulation treatment of hypotension 19 2011
8,204,598 Methods and apparatus for treating bronchial restriction using electrical modulation 16 2011
8,483,835 Methods and apparatus for treating anaphylaxis using electrical modulation 1 2012
8,612,004 Electrical stimulation treatment of hypotension 0 2012
8,983,628 Non-invasive vagal nerve stimulation to treat disorders 0 2012
8,983,629 Non-invasive vagal nerve stimulation to treat disorders 0 2012
8,918,178 Non-invasive vagal nerve stimulation to treat disorders 1 2012
9,233,242 Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders 0 2012
9,126,050 Non-invasive vagus nerve stimulation devices and methods to treat or avert atrial fibrillation 0 2013
8,666,496 Methods and apparatus for electrical treatment using balloon and electrode 3 2013
9,248,286 Medical self-treatment using non-invasive vagus nerve stimulation 0 2013
9,254,383 Devices and methods for monitoring non-invasive vagus nerve stimulation 0 2013
8,880,175 Systems and methods for selectively applying electrical energy to tissue 0 2013
8,972,004 Magnetic stimulation devices and methods of therapy 0 2013
9,043,001 Methods and devices for treating primary headache 0 2013
9,020,598 Methods and devices for treating primary headache 0 2013
9,014,823 Methods and devices for treating primary headache 0 2013
9,205,258 Nerve stimulator system 0 2013
8,948,873 Electrical stimulation treatment of hypotension 0 2013
9,174,049 Systems and methods for electrical stimulation of sphenopalatine ganglion and other branches of cranial nerves 0 2014
9,067,054 Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient 0 2014
9,233,246 Methods and devices for treating primary headache 0 2014
8,934,977 Methods and apparatus for treating anaphylaxis using electrical modulation 0 2014
9,333,347 Devices and methods for non-invasive electrical stimulation and their use for vagal nerve stimulation on the neck of a patient 0 2014
9,327,118 Non-invasive treatment of bronchial constriction 0 2014
9,339,653 Electrical stimulation treatment of hypotension 0 2015
9,233,258 Magnetic stimulation devices and methods of therapy 0 2015
 
SETPOINT MEDICAL CORPORATION (12)
8,412,338 Devices and methods for optimizing electrode placement for anti-inflamatory stimulation 9 2009
* 2010/0125,304 DEVICES AND METHODS FOR OPTIMIZING ELECTRODE PLACEMENT FOR ANTI-INFLAMATORY STIMULATION 29 2009
8,886,339 Nerve cuff with pocket for leadless stimulator 2 2010
* 2010/0312,320 NERVE CUFF WITH POCKET FOR LEADLESS STIMULATOR 48 2010
8,996,116 Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction 0 2010
8,612,002 Neural stimulation devices and systems for treatment of chronic inflammation 7 2010
* 2011/0190,849 NEURAL STIMULATION DEVICES AND SYSTEMS FOR TREATMENT OF CHRONIC INFLAMMATION 24 2010
8,788,034 Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation 3 2012
8,855,767 Neural stimulation devices and systems for treatment of chronic inflammation 4 2013
9,211,410 Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation 0 2014
9,162,064 Neural stimulation devices and systems for treatment of chronic inflammation 0 2014
9,174,041 Nerve cuff with pocket for leadless stimulator 0 2014
 
SANDISK ENTERPRISE IP, LLC (1)
9,283,390 Methods and apparatus for treating anaphylaxis using electrical modulation 0 2015
 
MEDTRONIC, INC. (151)
8,594,798 Multi-modal operation of a medical device system 0 2003
8,579,786 Screening techniques for management of a nervous system disorder 0 2003
8,543,214 Configuring and testing treatment therapy parameters for a medical device system 0 2003
8,187,181 Scoring of sensed neurological signals for use with a medical device system 4 2003
7,715,919 Control of treatment therapy during start-up and during operation of a medical device system 11 2003
7,282,030 Timed delay for redelivery of treatment therapy for a medical device system 43 2003
7,280,867 Clustering of recorded patient neurological activity to determine length of a neurological event 50 2003
7,242,983 Channel-selective blanking for a medical device system 147 2003
7,149,572 Phase shifting of neurological signals in a medical device system 38 2003
7,146,211 Signal quality monitoring and control for a medical device system 62 2003
7,079,977 Synchronization and calibration of clocks for a medical device and calibrated clock 89 2003
* 2004/0138,518 Medical device system with relaying module for treatment of nervous system disorders 79 2003
* 2004/0138,580 Signal quality monitoring and control for a medical device system 23 2003
* 2004/0138,536 Clustering of recorded patient neurological activity to determine length of a neurological event 44 2003
* 2004/0138,711 Control of treatment therapy during start-up and during operation of a medical device system 113 2003
* 2004/0138,647 Cycle mode providing redundant back-up to ensure termination of treatment therapy in a medical device system 107 2003
* 2004/0138,516 Configuring and testing treatment therapy parameters for a medical device system 113 2003
* 2004/0138,517 Multi-modal operation of a medical device system 158 2003
* 2004/0133,119 Scoring of sensed neurological signals for use with a medical device system 123 2003
* 2004/0133,248 Channel-selective blanking for a medical device system 63 2003
* 2004/0133,120 Phase shifting of neurological signals in a medical device system 10 2003
8,396,565 Automatic therapy adjustments 2 2003
* 2007/0203,531 Heart rate variability control of gastric electrical stimulator 4 2004
* 2005/0245,986 Heart rate variability control of gastric electrical stimulator 11 2004
8,694,115 Therapy programming guidance based on stored programming history 0 2005
* 2006/0020,292 Therapy programming guidance based on stored programming history 73 2005
8,041,418 System and method for regulating cardiac triggered therapy to the brain 0 2005
8,041,419 System and method for monitoring or treating nervous system disorders 3 2005
7,949,391 System and method for regulating cardiac triggered therapy to the brain 0 2005
7,949,392 System and method for monitoring or treating nervous system disorders 0 2005
7,945,316 System and method for monitoring or treating nervous system disorders 3 2005
7,865,244 System and method for regulating cardiopulmonary triggered therapy to the brain 8 2005
7,787,944 System and method for regulating cardiac triggered therapy to the brain 0 2005
7,684,855 System and method for regulating cardiac triggered therapy to the brain 0 2005
7,680,539 System and method for regulating cardiopulmonary triggered therapy to the brain 0 2005
* 2006/0135,881 System and method for monitoring or treating nervous system disorders 70 2005
7,624,293 Synchronization and calibration of clocks for a medical device and calibrated clock 15 2006
7,321,837 Synchronization and calibration of clocks for a medical device and calibrated clock 40 2006
* 2006/0155,495 Synchronization and calibration of clocks for a medical device and calibrated clock 55 2006
7,819,909 Therapy programming guidance based on stored programming history 3 2006
* 2006/0235,472 Therapy programming guidance based on stored programming history 100 2006
8,108,038 System and method for segmenting a cardiac signal based on brain activity 5 2006
* 2006/0224,067 SYSTEM AND METHOD FOR SEGMENTING A CARDIAC SIGNAL BASED ON BRAIN ACTIVITY 89 2006
8,326,431 Implantable medical device for the concurrent treatment of a plurality of neurological disorders and method therefore 0 2006
7,853,322 Closed-loop therapy adjustment 11 2006
* 2007/0255,323 Implantable medical device for the concurrent treatment of a plurality of neurological disorders and method therefore 8 2006
* 2007/0129,774 Closed-loop therapy adjustment 63 2006
7,976,465 Phase shifting of neurological signals in a medical device system 1 2006
7,917,206 Signal quality monitoring and control for a medical device system 8 2006
8,190,251 Method and apparatus for the treatment of movement disorders 1 2006
* 2007/0225,674 Method and Apparatus for the Treatment of Movement Disorders 60 2006
7,957,797 Closed-loop therapy adjustment 15 2006
7,957,809 Closed-loop therapy adjustment 29 2006
* 2007/0150,029 Closed-loop therapy adjustment 84 2006
* 2007/0150,026 Closed-loop therapy adjustment 46 2006
8,165,683 Method and apparatus for detection of nervous system disorders 0 2006
7,764,989 Method and apparatus for detection of nervous system disorders 4 2006
7,761,145 Method and apparatus for detection of nervous system disorders 8 2006
7,761,146 Method and apparatus for detection of nervous system disorders 5 2006
* 2008/0046,024 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 4 2006
* 2007/0265,544 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 2 2006
* 2007/0249,954 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 52 2006
* 2007/0249,953 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 56 2006
* 2007/0249,955 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 6 2006
7,979,130 Method and apparatus for detection of nervous system disorders 1 2007
* 2007/0250,133 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 8 2007
8,485,979 System and method for monitoring or treating nervous system disorders 0 2007
8,214,035 System and method for utilizing brain state information to modulate cardiac therapy 0 2007
8,209,009 System and method for segmenting a cardiac signal based on brain stimulation 3 2007
8,209,019 System and method for utilizing brain state information to modulate cardiac therapy 1 2007
8,112,153 System and method for monitoring or treating nervous system disorders 3 2007
8,068,911 System and method for regulating cardiopulmonary triggered therapy to the brain 0 2007
8,000,788 Implantable medical device for treating neurological conditions including ECG sensing 0 2007
* 2007/0260,286 System and method for utilizing brain state information to modulate cardiac therapy 29 2007
8,112,148 System and method for monitoring cardiac signal activity in patients with nervous system disorders 3 2007
8,108,046 System and method for using cardiac events to trigger therapy for treating nervous system disorders 3 2007
* 2007/0260,289 SYSTEM AND METHOD FOR USING CARDIAC EVENTS TO TRIGGER THERAPY FOR TREATING NERVOUS SYSTEM DISORDERS 82 2007
8,738,136 Clustering of recorded patient neurological activity to determine length of a neurological event 0 2007
7,933,646 Clustering of recorded patient neurological activity to determine length of a neurological event 5 2007
* 2008/0064,934 CLUSTERING OF RECORDED PATIENT NEUROLOGICAL ACTIVITY TO DETERMINE LENGTH OF A NEUROLOGICAL EVENT 51 2007
9,327,070 Medical device therapy based on posture and timing 0 2009
9,327,129 Blended posture state classification and therapy delivery 0 2009
9,050,471 Posture state display on medical device user interface 1 2009
9,026,223 Therapy system including multiple posture sensors 0 2009
8,958,885 Posture state classification for a medical device 0 2009
8,886,302 Adjustment of posture-responsive therapy 0 2009
8,755,901 Patient assignment of therapy parameter to posture state 0 2009
8,751,011 Defining therapy parameter values for posture states 0 2009
8,708,934 Reorientation of patient posture states for posture-responsive therapy 0 2009
8,688,225 Posture state detection using selectable system control parameters 0 2009
8,644,945 Patient interaction with posture-responsive therapy 0 2009
8,583,252 Patient interaction with posture-responsive therapy 2 2009
8,515,549 Associating therapy adjustments with intended patient posture states 2 2009
8,515,550 Assignment of therapy parameter to multiple posture states 3 2009
8,447,411 Patient interaction with posture-responsive therapy 3 2009
8,437,861 Posture state redefinition based on posture data and therapy adjustments 2 2009
8,401,666 Modification profiles for posture-responsive therapy 12 2009
8,332,041 Patient interaction with posture-responsive therapy 7 2009
8,323,218 Generation of proportional posture information over multiple time intervals 20 2009
8,326,420 Associating therapy adjustments with posture states using stability timers 6 2009
8,315,710 Associating therapy adjustments with patient posture states 5 2009
8,282,580 Data rejection for posture state analysis 7 2009
8,249,718 Programming posture state-responsive therapy with nominal therapy parameters 3 2009
8,231,555 Therapy system including multiple posture sensors 10 2009
8,231,556 Obtaining baseline patient information 6 2009
8,219,206 Dwell time adjustments for posture state-responsive therapy 14 2009
8,209,028 Objectification of posture state-responsive therapy based on patient therapy adjustments 49 2009
8,200,340 Guided programming for posture-state responsive therapy 14 2009
8,175,720 Posture-responsive therapy control based on patient input 6 2009
8,150,531 Associating therapy adjustments with patient posture states 7 2009
* 2010/0010,587 GUIDED PROGRAMMING FOR POSTURE-STATE RESPONSIVE THERAPY 39 2009
* 2010/0010,585 PROGRAMMING POSTURE RESPONSIVE THERAPY 44 2009
* 2010/0010,432 ASSOCIATING THERAPY ADJUSTMENTS WITH PATIENT POSTURE STATES 42 2009
* 2010/0010,578 PATIENT ASSIGNMENT OF THERAPY PARAMETER TO POSTURE STATE 38 2009
* 2010/0010,382 BLENDED POSTURE STATE CLASSIFICATION AND THERAPY DELIVERY 58 2009
* 2010/0010,577 LINKING POSTURE STATES FOR POSTURE RESPONSIVE THERAPY 40 2009
* 2010/0010,391 POSTURE STATE REDEFINITION BASED ON POSTURE DATA 40 2009
* 2010/0010,575 PATIENT INTERACTION WITH POSTURE-RESPONSIVE THERAPY 40 2009
* 2010/0010,381 POSTURE STATE RESPONSIVE THERAPY DELIVERY USING DWELL TIMES 52 2009
* 2010/0010,580 DEFINING THERAPY PARAMETER VALUES FOR POSTURE STATES 48 2009
* 2010/0010,574 POSTURE STATE REDEFINITION BASED ON POSTURE DATA AND THERAPY ADJUSTMENTS 48 2009
* 2010/0010,390 DWELL TIME ADJUSTMENTS FOR POSTURE STATE-RESPONSIVE THERAPY 41 2009
* 2010/0010,384 POSTURE STATE DETECTION USING SELECTABLE SYSTEM CONTROL PARAMETERS 40 2009
* 2010/0010,586 OBJECTIFICATION OF POSTURE STATE-RESPONSIVE THERAPY BASED ON PATIENT THERAPY ADJUSTMENTS 39 2009
* 2010/0010,383 REORIENTATION OF PATIENT POSTURE STATES FOR POSTURE-RESPONSIVE THERAPY 48 2009
* 2010/0010,388 ASSOCIATING THERAPY ADJUSTMENTS WITH INTENDED PATIENT POSTURE STATES 40 2009
8,280,517 Automatic validation techniques for validating operation of medical devices 4 2009
8,068,903 Method and apparatus for detection of nervous system disorders 0 2010
* 2010/0130,881 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 0 2010
8,792,986 Treatment of the autonomic nervous system 1 2010
9,149,210 Automated calibration of posture state classification for a medical device 0 2010
8,758,274 Automated adjustment of posture state definitions for a medical device 0 2010
8,388,555 Posture state classification for a medical device 4 2010
* 2011/0172,927 AUTOMATED ADJUSTMENT OF POSTURE STATE DEFINITIONS FOR A MEDICAL DEVICE 1 2010
* 2011/0172,567 POSTURE STATE CLASSIFICATION FOR A MEDICAL DEVICE 2 2010
8,761,868 Method for monitoring or treating nervous system disorders 0 2010
8,744,562 Method for monitoring or treating nervous system disorders 1 2010
8,903,486 Closed-loop therapy adjustment 0 2010
8,579,834 Display of detected patient posture state 6 2011
* 2011/0172,743 DISPLAY OF DETECTED PATIENT POSTURE STATE 1 2011
8,731,656 Closed-loop therapy adjustment 0 2011
* 2011/0238,130 CLOSED-LOOP THERAPY ADJUSTMENT 1 2011
* 2011/0238,136 CLOSED-LOOP THERAPY ADJUSTMENT 3 2011
9,014,804 Implantable medical device for treating neurological conditions including ECG sensing 0 2011
8,527,039 Method and apparatus for detection of nervous system disorders 0 2011
8,504,150 Associating therapy adjustments with posture states using a stability timer 0 2012
* 8,504,161 Modulate vagal signals to reduce inflammation 1 2012
8,905,948 Generation of proportional posture information over multiple time intervals 0 2012
9,174,055 Display of detected patient posture state 0 2013
9,072,832 Clustering of recorded patient neurological activity to determine length of a neurological event 0 2014
9,272,091 Posture state display on medical device user interface 0 2015
 
OSORIO, IVAN (1)
8,880,167 Selective recruitment and activation of fiber types in nerves for the control of undesirable brain state changes 0 2013
 
Flint Hills Scientific, LLC (23)
7,389,144 Medical device failure detection and warning system 50 2004
9,050,469 Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals 0 2004
8,515,538 Medical device failure detection and warning system 2 2008
8,417,344 Dynamic cranial nerve stimulation based on brain state determination from cardiac data 0 2008
* 2010/0106,217 DYNAMIC CRANIAL NERVE STIMULATION BASED ON BRAIN STATE DETERMINATION FROM CARDIAC DATA 25 2008
8,634,922 Vagal nerve stimulation techniques for treatment of epileptic seizures 0 2008
8,562,536 Algorithm for detecting a seizure from cardiac data 0 2010
8,679,009 Systems approach to comorbidity assessment 2 2010
8,571,643 Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex 0 2010
8,452,387 Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex 0 2010
8,337,404 Detecting, quantifying, and/or classifying seizures using multimodal data 3 2010
8,562,523 Detecting, assessing and managing extreme epileptic events 0 2011
8,562,524 Detecting, assessing and managing a risk of death in epilepsy 2 2011
8,382,667 Detecting, quantifying, and/or classifying seizures using multimodal data 3 2011
8,684,921 Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis 0 2012
9,314,633 Contingent cardio-protection for epilepsy patients 0 2012
8,888,702 Detecting, quantifying, and/or classifying seizures using multimodal data 0 2012
8,852,100 Detecting, quantifying, and/or classifying seizures using multimodal data 1 2013
8,849,409 Dynamic cranial nerve stimulation based on brain state determination from cardiac data 0 2013
8,768,471 Dynamic cranial nerve stimulation based on brain state determination from cardiac data 0 2013
8,948,855 Detecting and validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex 0 2013
9,095,314 Medical device failure detection and warning system 0 2013
9,020,582 Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex 0 2013
 
MARVELL INTERNATIONAL LTD. (1)
6,892,098 Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders 56 2002
 
BIO CONTROL MEDICAL (B.C.M.) LTD. (37)
7,734,355 Treatment of disorders by unidirectional nerve stimulation 56 2002
7,778,703 Selective nerve fiber stimulation for treating heart conditions 68 2002
6,907,295 Electrode assembly for nerve control 193 2002
* 2003/0045,909 Selective nerve fiber stimulation for treating heart conditions 314 2002
7,613,516 Pelvic disorder treatment device 32 2002
7,321,793 Vagal stimulation for atrial fibrillation therapy 96 2003
7,778,711 Reduction of heart rate variability by parasympathetic stimulation 39 2003
* 2004/0193,231 Selective nerve fiber stimulation for treating heart conditions 156 2003
7,890,185 Treatment of disorders by unidirectional nerve stimulation 22 2003
* 2004/0172,094 Treatment of disorders by unidirectional nerve stimulation 100 2003
7,885,711 Vagal stimulation for anti-embolic therapy 18 2004
7,346,398 Electrode assembly for nerve control 99 2004
7,324,853 Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders 44 2004
7,561,922 Construction of electrode assembly for nerve control 32 2004
7,634,317 Techniques for applying, calibrating, and controlling nerve fiber stimulation 49 2005
7,974,693 Techniques for applying, configuring, and coordinating nerve fiber stimulation 23 2005
8,386,056 Parasympathetic stimulation for treating atrial arrhythmia and heart failure 1 2005
* 2005/0216,069 Pelvic disorder treatment device 13 2005
7,885,709 Nerve stimulation for treating disorders 22 2005
* 2006/0100,668 Selective nerve fiber stimulation 151 2005
7,627,384 Techniques for nerve stimulation 19 2005
8,609,082 Administering bone marrow progenitor cells or myoblasts followed by application of an electrical current for cardiac repair, increasing blood supply or enhancing angiogenesis 0 2006
7,844,346 Electrode assembly for nerve control 18 2006
7,904,176 Techniques for reducing pain associated with nerve stimulation 16 2006
8,204,591 Techniques for prevention of atrial fibrillation 5 2007
8,060,197 Parasympathetic stimulation for termination of non-sinus atrial tachycardia 13 2007
8,116,881 Electrode assembly for nerve control 14 2007
8,005,542 Therapeutic maintenance of atrial fibrillation by electrical stimulation 15 2007
8,326,438 Techniques for nerve stimulation 2 2009
8,718,791 Electrode cuffs 0 2010
8,565,896 Electrode cuff with recesses 2 2010
8,571,651 Techniques for reducing pain associated with nerve stimulation 0 2011
8,571,653 Nerve stimulation techniques 4 2011
8,494,655 Electrode devices with resistive elements 1 2011
8,880,192 Electrode cuffs 0 2012
8,909,355 Techniques for nerve stimulation 0 2012
8,725,271 Electrode device with elongated electrode 0 2013
 
ASTORA WOMEN'S HEALTH, LLC (11)
6,862,480 Pelvic disorder treatment device 76 2001
8,195,296 Apparatus for treating stress and urge incontinence 20 2006
* 2007/0260,288 Apparatus for treating stress and urge incontinence 22 2006
8,160,710 Systems and methods for implanting tissue stimulation electrodes in the pelvic region 1 2007
8,340,786 Incontinence treatment device 3 2008
* 2008/0242,918 Incontinence Treatment Device 2 2008
8,083,663 Pelvic disorder treatment 15 2009
* 2009/0254,145 PELVIC DISORDER TREATMENT 3 2009
8,380,312 Multi-zone stimulation implant system and method 0 2010
8,774,942 Tissue anchor 11 2012
9,220,887 Electrode lead including a deployable tissue anchor 0 2012
 
Pacesetter, Inc. (5)
* 7,123,961 Stimulation of autonomic nerves 135 2004
7,676,275 Endovascular lead for chronic nerve stimulation 22 2005
* 7,869,869 Subcardiac threshold vagal nerve stimulation 14 2006
* 7,813,805 Subcardiac threshold vagal nerve stimulation 20 2006
* 8,473,068 Subcardiac threshold vagal nerve stimulation 0 2010
 
CYBERONCS, INC. (1)
8,874,229 Delivering scheduled and unscheduled therapy without detriment to battery life or accuracy of longevity predictions 0 2010
 
CATHOLIC HEALTHCARE WEST (D/B/A ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER) (11)
8,615,309 Microburst electrical stimulation of cranial nerves for the treatment of medical conditions 0 2007
8,219,188 Synchronization of vagus nerve stimulation with the cardiac cycle of a patient 6 2007
8,150,508 Vagus nerve stimulation method 8 2007
* 2007/0233,194 SYNCHRONIZATION OF VAGUS NERVE STIMULATION WITH THE CARDIAC CYCLE OF A PATIENT 22 2007
* 2007/0233,192 VAGUS NERVE STIMULATION METHOD 65 2007
8,738,126 Synchronization of vagus nerve stimulation with the cardiac cycle of a patient 1 2009
8,660,666 Microburst electrical stimulation of cranial nerves for the treatment of medical conditions 1 2009
8,280,505 Vagus nerve stimulation method 7 2009
* 2010/0063,563 MICROBURST ELECTRICAL STIMULATION OF CRANIAL NERVES FOR THE TREATMENT OF MEDICAL CONDITIONS 12 2009
* 2009/0177,252 SYNCHRONIZATION OF VAGUS NERVE STIMULATION WITH THE CARDIAC CYCLE OF A PATIENT 8 2009
* 2009/0171,405 VAGUS NERVE STIMULATION METHOD 14 2009
 
Brainsgate Ltd. (9)
7,561,919 SPG stimulation via the greater palatine canal 17 2006
* 2006/0287,677 SPG stimulation via the greater palatine canal 7 2006
8,010,189 SPG stimulation for treating complications of subarachnoid hemorrhage 3 2007
7,908,000 Transmucosal electrical stimulation 4 2007
* 2009/0131,739 EXTERNAL MAGNETIC FIELD STIMULATION OF THE SPG 7 2008
8,954,149 External stimulation of the SPG 1 2011
8,406,869 Post-acute electrical stimulation treatment of adverse cerebrovascular events 2 2011
8,958,881 Neuroprotective electrical stimulation 1 2013
9,233,245 SPG stimulation 0 2015
 
Zabara, Jacob (1)
8,700,163 Cranial nerve stimulation for treatment of substance addiction 1 2005
 
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (7)
8,914,114 Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation 2 2004
* 2005/0125,044 Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation 80 2004
8,729,129 Neural tourniquet 4 2005
* 2008/0140,138 Inhibition of inflammatory cytokine production by stimulation of brain muscarinic receptors 13 2007
* 2009/0248,097 INHIBITION OF INFLAMMATORY CYTOKINE PRODUCTION BY CHOLINERGIC AGONISTS AND VAGUS NERVE STIMULATION 24 2008
8,391,970 Devices and methods for inhibiting granulocyte activation by neural stimulation 10 2008
9,211,409 Methods and systems for reducing inflammation by neuromodulation of T-cell activity 0 2009
 
RALSTON TECHNOLOGY GROUP, INC. (1)
* 2004/0153,436 Automated information management system and methods 15 2003
 
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (8)
* 7,228,167 Method and apparatus for detecting vagus nerve stimulation 46 2004
* 2006/0020,298 Systems and methods for curbing appetite 41 2004
7,803,195 Obesity treatment and device 27 2005
* 2005/0273,060 Obesity treatment and device 121 2005
* 2006/0020,277 Gastric reshaping devices and methods 55 2005
8,372,158 Obesity treatment and device 5 2010
* 2011/0009,980 OBESITY TREATMENT AND DEVICE 3 2010
8,911,393 Obesity treatment and device 0 2013
 
NEUROSYSTEC CORPORATION (3)
* 2011/0077,579 Cochlear implant with localized fluid transport 8 2006
* 2008/0152,694 Devices, Systems and Methods for Ophthalmic Drug Delivery 19 2007
* 2008/0065,002 Catheter for Localized Drug Delivery and/or Electrical Stimulation 6 2007
 
BIO NEURONICS CORPORATION (1)
* 2008/0114,417 Systems and methods of reducing artifact in neurological stimulation systems 69 2006
 
AMS RESEARCH CORPORATION (3)
* 2009/0043,356 Electrode Sling for Treating Stress and Urge Incontinence 7 2007
* 2009/0036,946 PELVIC DISORDER TREATMENTS 5 2008
* 2010/0217,340 Implantable Medical Device Connector System 2 2010
 
CVRX, INC. (26)
8,086,314 Devices and methods for cardiovascular reflex control 13 2002
7,840,271 Stimulus regimens for cardiovascular reflex control 56 2005
* 2005/0251,212 Stimulus regimens for cardiovascular reflex control 100 2005
* 2007/0021,794 Baroreflex Therapy for Disordered Breathing 46 2006
8,290,595 Method and apparatus for stimulation of baroreceptors in pulmonary artery 6 2006
8,060,206 Baroreflex modulation to gradually decrease blood pressure 15 2006
* 7,813,812 Baroreflex stimulator with integrated pressure sensor 26 2006
* 2007/0038,255 Baroreflex stimulator with integrated pressure sensor 61 2006
8,838,246 Devices and methods for cardiovascular reflex treatments 0 2006
* 2007/0060,972 DEVICES AND METHODS FOR CARDIOVASCULAR REFLEX TREATMENTS 66 2006
8,606,359 System and method for sustained baroreflex stimulation 2 2007
* 2008/0215,111 Devices and Methods for Cardiovascular Reflex Control 9 2007
* 2008/0177,350 Expandable Stimulation Electrode with Integrated Pressure Sensor and Methods Related Thereto 19 2007
* 2008/0172,101 NON-LINEAR ELECTRODE ARRAY 43 2007
* 2008/0171,923 ASSESSING AUTONOMIC ACTIVITY USING BAROREFLEX ANALYSIS 24 2007
* 2008/0097,540 ECG INPUT TO IMPLANTABLE PULSE GENERATOR USING CAROTID SINUS LEADS 18 2007
* 2009/0234,418 DEVICES AND METHODS FOR CARDIOVASCULAR REFLEX CONTROL VIA COUPLED ELECTRODES 15 2009
7,949,400 Devices and methods for cardiovascular reflex control via coupled electrodes 13 2009
* 2010/0174,347 DEVICES AND METHODS FOR CARDIOVASCULAR REFLEX CONTROL VIA COUPLED ELECTRODES 10 2009
8,583,236 Devices and methods for cardiovascular reflex control 0 2010
* 2010/0179,614 DEVICES AND METHODS FOR CARDIOVASCULAR REFLEX CONTROL 6 2010
8,718,789 Electrode structures and methods for their use in cardiovascular reflex control 1 2010
* 2010/0249,874 BAROREFLEX THERAPY FOR DISORDERED BREATHING 4 2010
9,044,609 Electrode structures and methods for their use in cardiovascular reflex control 0 2011
8,712,531 Automatic baroreflex modulation responsive to adverse event 1 2012
8,880,190 Electrode structures and methods for their use in cardiovascular reflex control 0 2012
 
NEUROVISTA CORPORATION (2)
* 2010/0023,089 Controlling a Subject's Susceptibility to a Seizure 24 2009
* 2010/0125,219 MINIMALLY INVASIVE SYSTEM FOR SELECTING PATIENT-SPECIFIC THERAPY PARAMETERS 47 2010
 
Cardiac Pacemakers, Inc. (37)
7,657,312 Multi-site ventricular pacing therapy with parasympathetic stimulation 60 2003
* 2005/0096,705 Multi-site ventricular pacing therapy with parasympathetic stimulation 105 2003
8,126,560 Stimulation lead for stimulating the baroreceptors in the pulmonary artery 10 2003
8,024,050 Lead for stimulating the baroreceptors in the pulmonary artery 18 2003
7,509,166 Automatic baroreflex modulation responsive to adverse event 79 2003
* 2005/0149,155 Stimulation lead for stimulating the baroreceptors in the pulmonary artery 138 2003
* 2005/0149,156 Lead for stimulating the baroreceptors in the pulmonary artery 152 2003
8,200,331 System and method for filtering neural stimulation 6 2004
* 2006/0095,080 System and method for filtering neural stimulation 51 2004
8,126,559 Neural stimulation with avoidance of inappropriate stimulation 9 2004
7,840,266 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 31 2005
7,660,628 System to provide myocardial and neural stimulation 52 2005
7,881,782 Neural stimulation system to prevent simultaneous energy discharges 12 2005
* 2006/0241,699 Neural stimulation system to prevent simultaneous energy discharges 49 2005
* 7,570,999 Implantable device for treating epilepsy and cardiac rhythm disorders 65 2005
8,131,359 System and method to deliver therapy in presence of another therapy 6 2008
* 2008/0200,959 System and method to deliver therapy in presence of another therapy 13 2008
9,314,635 Automatic baroreflex modulation responsive to adverse event 0 2009
8,131,362 Combined neural stimulation and cardiac resynchronization therapy 18 2009
8,200,332 System and method for filtering neural stimulation 5 2009
8,478,397 System to provide myocardial and neural stimulation 1 2010
8,406,876 Closed loop neural stimulation synchronized to cardiac cycles 3 2010
8,571,655 Multi-site ventricular pacing therapy with parasympathetic stimulation 4 2010
9,020,595 Baroreflex activation therapy with conditional shut off 0 2010
8,483,823 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 0 2010
8,548,585 Concurrent therapy detection in implantable medical devices 2 2010
8,929,990 Transvascular neural stimulation device and method for treating hypertension 0 2010
8,831,718 Neural stimulation system to prevent simultaneous energy discharges 0 2011
8,473,076 Lead for stimulating the baroreceptors in the pulmonary artery 2 2011
8,682,434 Neural stimulation with avoidance of inappropriate stimulation 2 2012
8,504,149 System and method to deliver therapy in presence of another therapy 0 2012
8,768,462 System and method for filtering neural stimulation 0 2012
8,660,648 Implantable and rechargeable neural stimulator 1 2012
9,211,412 Closed loop neural stimulation synchronized to cardiac cycles 0 2013
* 8,838,239 Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 0 2013
8,805,494 System and method to deliver therapy in presence of another therapy 0 2013
9,227,068 Concurrent therapy detection in implantable medical devices 0 2013
 
VENTURI GROUP, LLC (3)
* 2007/0073,354 Neural blocking therapy 57 2005
8,798,754 Neural blocking therapy 0 2008
* 2008/0154,333 NEURAL BLOCKING THERAPY 10 2008
 
EnteroMedics Inc. (40)
7,489,969 Vagal down-regulation obesity treatment 34 2003
* 2004/0172,086 Nerve conduction block treatment 78 2003
* 2004/0172,085 Nerve stimulation and conduction block therapy 135 2003
7,444,183 Intraluminal electrode apparatus and method 93 2004
7,167,750 Obesity treatment with electrically induced vagal down regulation 216 2004
* 2004/0172,088 Intraluminal electrode apparatus and method 70 2004
* 2004/0167,583 Electrode band apparatus and method 51 2004
* 2005/0070,970 Movement disorder stimulation with neural block 81 2004
7,844,338 High frequency obesity treatment 30 2004
* 2005/0038,484 Controlled vagal blockage therapy 161 2004
7,833,279 Pancreatic exocrine secretion diversion apparatus and method 5 2004
* 2006/0106,332 Pancreatic exocrine secretion diversion apparatus and method 46 2004
7,613,515 High frequency vagal blockage therapy 48 2005
* 2005/0131,485 High frequency vagal blockage therapy 150 2005
7,822,486 Custom sized neural electrodes 34 2005
7,672,727 Neural electrode treatment 11 2005
* 2007/0043,411 Neural electrode 25 2005
* 2007/0043,400 Neural electrode treatment 34 2005
7,986,995 Bulimia treatment 11 2007
7,720,540 Pancreatitis treatment 12 2007
7,693,577 Irritable bowel syndrome treatment 12 2007
7,630,769 GI inflammatory disease treatment 16 2007
* 2007/0142,870 Irritable bowel syndrome treatment 34 2007
* 2007/0135,846 Vagal obesity treatment 43 2007
* 2007/0135,856 Bulimia treatment 35 2007
* 2007/0135,858 Pancreatitis treatment 33 2007
7,729,771 Nerve stimulation and blocking for treatment of gastrointestinal disorders 20 2007
* 2008/0021,512 Nerve stimulation and blocking for treatment of gastrointestinal disorders 65 2007
8,103,349 Neural electrode treatment 15 2009
8,010,204 Nerve blocking for treatment of gastrointestinal disorders 9 2010
8,617,095 Pancreatic exocrine secretion diversion apparatus and method 0 2010
8,046,085 Controlled vagal blockage therapy 20 2010
* 2011/0034,968 CONTROLLED VAGAL BLOCKAGE THERAPY 6 2010
8,825,164 Neural modulation devices and methods 0 2011
8,369,952 Bulimia treatment 4 2011
8,538,542 Nerve stimulation and blocking for treatment of gastrointestinal disorders 1 2011
8,538,533 Controlled vagal blockage therapy 0 2011
8,862,233 Electrode band system and methods of using the system to treat obesity 0 2013
9,174,040 Nerve stimulation and blocking for treatment of gastrointestinal disorders 0 2013
9,162,062 Controlled vagal blockage therapy 0 2013
 
RAINBOW MEDICAL LTD. (1)
9,186,504 Sleep apnea treatment 0 2014
 
BLUEWIND MEDICAL LTD. (1)
8,755,893 Tibial nerve stimulation 3 2012
 
Kwalata Trading Ltd. (5)
8,685,724 In vitro techniques for use with stem cells 0 2005
* 2008/0220,466 In Vitro Techniques For Use With Stem Cells 3 2005
* 2006/0110,374 Method to accelerate stem cell recruitment and homing 11 2005
8,541,232 Composition comprising a progenitor/precursor cell population 1 2007
9,234,173 Regulating stem cells 0 2013
 
JAMES HARDIE TECHNOLOGY LIMITED (1)
* 2008/0096,018 Engineered low-density heterogeneous microparticles and methods and formulations for producing the microparticles 18 2006
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (34)
* 7,860,570 Implantable microstimulators and methods for unidirectional propagation of action potentials 120 2002
* 7,292,890 Vagus nerve stimulation via unidirectional propagation of action potentials 229 2002
* 7,203,548 Cavernous nerve stimulation via unidirectional propagation of action potentials 99 2002
* 2004/0015,205 Implantable microstimulators with programmable multielectrode configuration and uses thereof 209 2002
* 2004/0015,204 Implantable microstimulators and methods for unidirectional propagation of action potentials 138 2002
* 2003/0236,558 Vagus nerve stimulation via unidirectional propagation of action potentials 101 2002
* 2003/0236,557 Cavernous nerve stimulation via unidirectional propagation of action potentials 35 2002
7,308,303 Thrombolysis and chronic anticoagulation therapy 23 2002
7,167,751 Method of using a fully implantable miniature neurostimulator for vagus nerve stimulation 92 2004
7,627,383 Implantable stimulator 6 2005
7,660,631 Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction 7 2005
7,801,600 Controlling charge flow in the electrical stimulation of tissue 10 2005
* 2005/0240,229 Methods and systems for stimulation as a therapy for erectile dysfunction 65 2005
8,175,717 Ultracapacitor powered implantable pulse generator with dedicated power supply 14 2005
* 2007/0055,308 Ultracapacitor powered implantable pulse generator with dedicated power supply 39 2005
7,729,758 Magnetically coupled microstimulators 18 2005
* 2007/0123,938 Magnetically coupled microstimulators 30 2005
7,890,177 Device and therapy for erectile dysfunction and other sexual dysfunction 1 2006
7,865,243 Device and therapy for erectile dysfunction and other sexual dysfunction 2 2006
7,801,602 Controlling stimulation parameters of implanted tissue stimulators 9 2006
* 2006/0229,688 Controlling stimulation parameters of implanted tissue stimulators 50 2006
7,899,539 Cavernous nerve stimulation via unidirectional propagation of action potentials 14 2006
* 2007/0021,800 CAVERNOUS NERVE STIMULATION VIA UNIDIRECTIONAL PROPAGATION OF ACTION POTENTIALS 25 2006
* 2007/0083,240 Methods and systems for applying stimulation and sensing one or more indicators of cardiac activity with an implantable stimulator 15 2006
7,877,136 Enhancement of neural signal transmission through damaged neural tissue via hyperpolarizing electrical stimulation current 59 2007
7,783,362 Vagus nerve stimulation via unidirectional propagation of action potentials 6 2007
7,877,137 Thrombolysis and chronic anticoagulation therapy 0 2007
* 2008/0286,327 THOMBOLYSIS AND CHRONIC ANTICOAGULATION THERAPY 0 2007
8,600,512 Methods and systems for treating seizures caused by brain stimulation 0 2008
* 2010/0280,575 CONTROLLING CHARGE FLOW IN THE ELECTRICAL STIMULATION OF TISSUE 1 2010
8,548,604 Implantable microstimulators and methods for unidirectional propagation of action potentials 1 2010
8,712,547 Cavernous nerve stimulation via unidirectional propagation of action potentials 0 2011
9,283,394 Implantable microstimulators and methods for unidirectional propagation of action potentials 0 2013
9,031,656 Methods and systems for treating seizures caused by brain stimulation 0 2013
 
BIO NEURONICS CORPORATION (1)
8,295,934 Systems and methods of reducing artifact in neurological stimulation systems 1 2006
 
Flunt Hills Scientific, LLC (1)
8,945,006 Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis 1 2014
 
NEVRO CORPORATION (55)
* 2009/0204,173 Multi-Frequency Neural Treatments and Associated Systems and Methods 80 2008
8,255,057 Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions 23 2009
8,838,248 Devices for controlling high frequency spinal cord modulation for inhibiting pain, and associated systems and methods, including simplified program selection 1 2010
8,712,533 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 7 2010
8,694,108 Devices for controlling high frequency spinal cord modulation for inhibiting pain, and associated systems and methods, including simplified controllers 0 2010
* 2010/0274,314 SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS 73 2010
* 2010/0274,316 DEVICES FOR CONTROLLING HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN, AND ASSOCIATED SYSTEMS AND METHODS, INCLUDING SIMPLIFIED CONTROLLERS 58 2010
* 2010/0274,317 DEVICES FOR CONTROLLING HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN, AND ASSOCIATED SYSTEMS AND METHODS, INCLUDING SIMPLIFIED CONTACT SELECTION 61 2010
8,423,147 Devices for controlling high frequency spinal cord modulation for inhibiting pain, and associated systems and methods, including simplified controllers 28 2011
8,209,021 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 31 2011
8,170,675 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 39 2011
8,649,874 Extended pain relief via high frequency spinal cord modulation, and associated systems and methods 10 2011
8,396,559 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 26 2012
8,509,905 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 1 2012
8,428,748 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 25 2012
8,359,102 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 34 2012
8,359,103 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 35 2012
8,355,792 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 31 2012
8,509,906 Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions 4 2012
9,327,121 Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods 0 2012
8,989,865 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2012
8,774,926 Multi-frequency neural treatments and associated systems and methods 0 2012
8,768,472 Multi-frequency neural treatments and associated systems and methods 0 2012
8,694,109 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2012
8,660,654 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2012
8,718,781 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2012
9,295,839 Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods 0 2013
9,283,387 Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods 0 2013
9,283,388 Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods 0 2013
9,278,215 Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods 0 2013
8,874,217 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2013
8,874,221 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2013
8,718,782 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 1 2013
8,676,331 Devices for controlling spinal cord modulation for inhibiting pain, and associated systems and methods, including controllers for automated parameter selection 8 2013
8,554,326 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 1 2013
8,849,410 Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions 0 2013
8,892,209 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 15 2013
8,862,239 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2013
8,792,988 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2013
9,180,298 Extended pain relief via high frequency spinal cord modulation, and associated systems and methods 3 2014
8,886,326 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 14 2014
8,886,327 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2014
8,880,177 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2014
8,874,222 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2014
8,868,192 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2014
9,002,460 Devices for controlling spinal cord modulation for inhibiting pain, and associated systems and methods, including controllers for automated parameter selection 1 2014
8,886,328 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 14 2014
9,327,125 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2014
9,248,293 Devices for controlling high frequency spinal cord modulation for inhibiting pain, and associated systems and methods, including simplified program selection 0 2014
9,333,357 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2014
9,333,358 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2014
9,333,359 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2014
9,333,360 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2014
9,327,126 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2014
9,327,127 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 0 2014
 
MEDTRONIC TRANSNEURONIX, INC. (2)
7,664,551 Treatment of the autonomic nervous system 12 2005
* 2006/0058,851 Treatment of the autonomic nervous system 37 2005
* Cited By Examiner