Vagal nerve stimulation techniques for treatment of epileptic seizures

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United States of America Patent

PATENT NO 6341236
SERIAL NO

09302516

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A system and method for using electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus nerve, and a sensor for sensing characteristics of the heart such as a heart rate. The heart rate information from the sensor can be used to determine whether the vagus nerve stimulation is adversely affecting the heart. Once threshold parameters are met, the vagus nerve stimulation may be stopped or adjusted. In an alternative embodiment, a modified pacemaker is used to maintain the heart in desired conditions during the vagus nerve stimulation. In yet another embodiment, a modified pacemaker having circuitry that determines whether a vagus nerve is being stimulated is used. In the event that the vagus nerve is being stimulated, the modified pacemaker may control the heart to maintain it within desired conditions during the vagus nerve stimulation.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
FLINT HILLS SCIENTIFIC, L.L.C.LAWRENCE, KS65

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Frei, Mark G 2513 via Linda Dr., Lawrence, KS 66047 65 4576
Osorio, Ivan 4005 W. 124th St., Leawood, KS 66209 142 6594

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (16)
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8112148 System and method for monitoring cardiac signal activity in patients with nervous system disorders 7 2007
8108046 System and method for using cardiac events to trigger therapy for treating nervous system disorders 4 2007
* 2007/0260,289 SYSTEM AND METHOD FOR USING CARDIAC EVENTS TO TRIGGER THERAPY FOR TREATING NERVOUS SYSTEM DISORDERS 89 2007
8738136 Clustering of recorded patient neurological activity to determine length of a neurological event 0 2007
7933646 Clustering of recorded patient neurological activity to determine length of a neurological event 7 2007
* 2008/0064,934 CLUSTERING OF RECORDED PATIENT NEUROLOGICAL ACTIVITY TO DETERMINE LENGTH OF A NEUROLOGICAL EVENT 55 2007
* 2008/0033,508 CLUSTERING OF RECORDED PATIENT NEUROLOGICAL ACTIVITY TO DETERMINE LENGTH OF A NEUROLOGICAL EVENT 54 2007
9545518 Posture state classification for a medical device 0 2009
9440084 Programming posture responsive therapy 0 2009
9327070 Medical device therapy based on posture and timing 2 2009
9327129 Blended posture state classification and therapy delivery 0 2009
9050471 Posture state display on medical device user interface 3 2009
9026223 Therapy system including multiple posture sensors 1 2009
8958885 Posture state classification for a medical device 0 2009
8886302 Adjustment of posture-responsive therapy 1 2009
8755901 Patient assignment of therapy parameter to posture state 1 2009
8751011 Defining therapy parameter values for posture states 1 2009
8708934 Reorientation of patient posture states for posture-responsive therapy 2 2009
8688225 Posture state detection using selectable system control parameters 0 2009
8644945 Patient interaction with posture-responsive therapy 1 2009
8583252 Patient interaction with posture-responsive therapy 3 2009
8515549 Associating therapy adjustments with intended patient posture states 4 2009
8515550 Assignment of therapy parameter to multiple posture states 5 2009
8447411 Patient interaction with posture-responsive therapy 5 2009
8437861 Posture state redefinition based on posture data and therapy adjustments 3 2009
8401666 Modification profiles for posture-responsive therapy 18 2009
8332041 Patient interaction with posture-responsive therapy 9 2009
8323218 Generation of proportional posture information over multiple time intervals 29 2009
8326420 Associating therapy adjustments with posture states using stability timers 9 2009
8315710 Associating therapy adjustments with patient posture states 7 2009
8282580 Data rejection for posture state analysis 10 2009
8249718 Programming posture state-responsive therapy with nominal therapy parameters 6 2009
8231555 Therapy system including multiple posture sensors 13 2009
8231556 Obtaining baseline patient information 9 2009
8219206 Dwell time adjustments for posture state-responsive therapy 22 2009
8209028 Objectification of posture state-responsive therapy based on patient therapy adjustments 56 2009
8200340 Guided programming for posture-state responsive therapy 23 2009
8175720 Posture-responsive therapy control based on patient input 12 2009
8150531 Associating therapy adjustments with patient posture states 11 2009
* 2010/0010,587 GUIDED PROGRAMMING FOR POSTURE-STATE RESPONSIVE THERAPY 44 2009
* 2010/0010,585 PROGRAMMING POSTURE RESPONSIVE THERAPY 50 2009
* 2010/0010,432 ASSOCIATING THERAPY ADJUSTMENTS WITH PATIENT POSTURE STATES 49 2009
* 2010/0010,578 PATIENT ASSIGNMENT OF THERAPY PARAMETER TO POSTURE STATE 43 2009
* 2010/0010,382 BLENDED POSTURE STATE CLASSIFICATION AND THERAPY DELIVERY 65 2009
* 2010/0010,577 LINKING POSTURE STATES FOR POSTURE RESPONSIVE THERAPY 45 2009
* 2010/0010,391 POSTURE STATE REDEFINITION BASED ON POSTURE DATA 45 2009
* 2010/0010,575 PATIENT INTERACTION WITH POSTURE-RESPONSIVE THERAPY 45 2009
* 2010/0010,381 POSTURE STATE RESPONSIVE THERAPY DELIVERY USING DWELL TIMES 58 2009
* 2010/0010,580 DEFINING THERAPY PARAMETER VALUES FOR POSTURE STATES 57 2009
* 2010/0010,574 POSTURE STATE REDEFINITION BASED ON POSTURE DATA AND THERAPY ADJUSTMENTS 57 2009
* 2010/0010,390 DWELL TIME ADJUSTMENTS FOR POSTURE STATE-RESPONSIVE THERAPY 46 2009
* 2010/0010,384 POSTURE STATE DETECTION USING SELECTABLE SYSTEM CONTROL PARAMETERS 45 2009
* 2010/0010,586 OBJECTIFICATION OF POSTURE STATE-RESPONSIVE THERAPY BASED ON PATIENT THERAPY ADJUSTMENTS 44 2009
* 2010/0010,383 REORIENTATION OF PATIENT POSTURE STATES FOR POSTURE-RESPONSIVE THERAPY 54 2009
* 2010/0010,388 ASSOCIATING THERAPY ADJUSTMENTS WITH INTENDED PATIENT POSTURE STATES 47 2009
* 2010/0010,386 DATA REJECTION FOR POSTURE STATE ANALYSIS 44 2009
* 2010/0010,588 ASSOCIATING THERAPY ADJUSTMENTS WITH PATIENT POSTURE STATES 44 2009
* 2010/0010,389 Generation of proportional posture information over multiple time intervals 47 2009
8280517 Automatic validation techniques for validating operation of medical devices 5 2009
8068903 Method and apparatus for detection of nervous system disorders 0 2010
* 2010/0130,881 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 1 2010
8792986 Treatment of the autonomic nervous system 4 2010
9149210 Automated calibration of posture state classification for a medical device 0 2010
8758274 Automated adjustment of posture state definitions for a medical device 0 2010
8388555 Posture state classification for a medical device 6 2010
* 2011/0172,927 AUTOMATED ADJUSTMENT OF POSTURE STATE DEFINITIONS FOR A MEDICAL DEVICE 4 2010
* 2011/0172,567 POSTURE STATE CLASSIFICATION FOR A MEDICAL DEVICE 2 2010
9566441 Detecting posture sensor signal shift or drift in medical devices 0 2010
* 2010/0292,753 Method and Apparatus for Detection of Nervous System Disorders 0 2010
8761868 Method for monitoring or treating nervous system disorders 0 2010
8744562 Method for monitoring or treating nervous system disorders 1 2010
8903486 Closed-loop therapy adjustment 3 2010
* 2011/0082,522 CLOSED-LOOP THERAPY ADJUSTMENT 2 2010
9357949 User interface that displays medical therapy and posture data 2 2011
8579834 Display of detected patient posture state 10 2011
* 2011/0172,743 DISPLAY OF DETECTED PATIENT POSTURE STATE 1 2011
8731656 Closed-loop therapy adjustment 3 2011
* 2011/0238,130 CLOSED-LOOP THERAPY ADJUSTMENT 1 2011
* 2011/0238,136 CLOSED-LOOP THERAPY ADJUSTMENT 6 2011
9014804 Implantable medical device for treating neurological conditions including ECG sensing 0 2011
8527039 Method and apparatus for detection of nervous system disorders 0 2011
8504150 Associating therapy adjustments with posture states using a stability timer 1 2012
9560990 Obtaining baseline patient information 0 2012
* 8504161 Modulate vagal signals to reduce inflammation 2 2012
8905948 Generation of proportional posture information over multiple time intervals 1 2012
9174055 Display of detected patient posture state 0 2013
9072832 Clustering of recorded patient neurological activity to determine length of a neurological event 0 2014
9272091 Posture state display on medical device user interface 1 2015
 
SANDISK ENTERPRISE IP LLC (1)
9283390 Methods and apparatus for treating anaphylaxis using electrical modulation 0 2015
 
FLINT HILLS SCIENTIFIC, L.L.C. (23)
7389144 Medical device failure detection and warning system 57 2004
9050469 Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals 1 2004
8515538 Medical device failure detection and warning system 2 2008
8417344 Dynamic cranial nerve stimulation based on brain state determination from cardiac data 0 2008
* 2010/0106,217 DYNAMIC CRANIAL NERVE STIMULATION BASED ON BRAIN STATE DETERMINATION FROM CARDIAC DATA 27 2008
8634922 Vagal nerve stimulation techniques for treatment of epileptic seizures 0 2008
8562536 Algorithm for detecting a seizure from cardiac data 2 2010
8679009 Systems approach to comorbidity assessment 2 2010
8571643 Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex 0 2010
8452387 Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex 1 2010
8337404 Detecting, quantifying, and/or classifying seizures using multimodal data 5 2010
8562523 Detecting, assessing and managing extreme epileptic events 0 2011
8562524 Detecting, assessing and managing a risk of death in epilepsy 2 2011
8382667 Detecting, quantifying, and/or classifying seizures using multimodal data 4 2011
8684921 Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis 0 2012
9314633 Contingent cardio-protection for epilepsy patients 0 2012
8888702 Detecting, quantifying, and/or classifying seizures using multimodal data 0 2012
8852100 Detecting, quantifying, and/or classifying seizures using multimodal data 1 2013
8849409 Dynamic cranial nerve stimulation based on brain state determination from cardiac data 0 2013
8768471 Dynamic cranial nerve stimulation based on brain state determination from cardiac data 0 2013
8948855 Detecting and validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex 0 2013
9095314 Medical device failure detection and warning system 0 2013
9020582 Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex 0 2013
 
MARVELL INTERNATIONAL LTD. (1)
6892098 Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders 81 2002
 
BIO CONTROL MEDICAL (B.C.M.) LTD. (47)
7734355 Treatment of disorders by unidirectional nerve stimulation 78 2002
6907295 Electrode assembly for nerve control 214 2002
7321793 Vagal stimulation for atrial fibrillation therapy 113 2003
7778711 Reduction of heart rate variability by parasympathetic stimulation 53 2003
* 2004/0193,231 Selective nerve fiber stimulation for treating heart conditions 165 2003
7890185 Treatment of disorders by unidirectional nerve stimulation 35 2003
* 2004/0172,094 Treatment of disorders by unidirectional nerve stimulation 107 2003
7885711 Vagal stimulation for anti-embolic therapy 29 2004
* 2006/0271,115 Vagal stimulation for anti-embolic therapy 64 2004
* 2005/0065,553 Applications of vagal stimulation 180 2004
7346398 Electrode assembly for nerve control 115 2004
* 2005/0038,490 Electrode assembly for nerve control 17 2004
7324853 Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders 63 2004
* 2005/0102,007 Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders 12 2004
7561922 Construction of electrode assembly for nerve control 42 2004
* 2006/0136,024 Construction of electrode assembly for nerve control 34 2004
7634317 Techniques for applying, calibrating, and controlling nerve fiber stimulation 65 2005
* 2005/0197,675 Techniques for applying, calibrating, and controlling nerve fiber stimulation 144 2005
7974693 Techniques for applying, configuring, and coordinating nerve fiber stimulation 35 2005
8386056 Parasympathetic stimulation for treating atrial arrhythmia and heart failure 2 2005
* 2005/0187,586 Selective nerve fiber stimulation for treating heart conditions 76 2005
7885709 Nerve stimulation for treating disorders 34 2005
* 2006/0100,668 Selective nerve fiber stimulation 181 2005
7627384 Techniques for nerve stimulation 30 2005
8609082 Administering bone marrow progenitor cells or myoblasts followed by application of an electrical current for cardiac repair, increasing blood supply or enhancing angiogenesis 0 2006
7844346 Electrode assembly for nerve control 27 2006
7904176 Techniques for reducing pain associated with nerve stimulation 26 2006
* 2008/0065,158 Techniques for reducing pain associated with nerve stimulation 70 2006
8204591 Techniques for prevention of atrial fibrillation 7 2007
* 2007/0179,543 Techniques for prevention of atrial fibrillation 43 2007
8060197 Parasympathetic stimulation for termination of non-sinus atrial tachycardia 22 2007
* 2007/0203,527 Parasympathetic stimulation for termination of non-sinus atrial tachycardia 25 2007
8116881 Electrode assembly for nerve control 23 2007
8005542 Therapeutic maintenance of atrial fibrillation by electrical stimulation 24 2007
* 2008/0125,825 Therapeutic maintenance of atrial fibrillation by electrical stimulation 4 2007
8083663 Pelvic disorder treatment 32 2009
* 2009/0254,145 PELVIC DISORDER TREATMENT 3 2009
8326438 Techniques for nerve stimulation 2 2009
8718791 Electrode cuffs 0 2010
8565896 Electrode cuff with recesses 5 2010
8571651 Techniques for reducing pain associated with nerve stimulation 0 2011
8571653 Nerve stimulation techniques 5 2011
* 2011/0224,749 NERVE STIMULATION TECHNIQUES 60 2011
8494655 Electrode devices with resistive elements 1 2011
8880192 Electrode cuffs 0 2012
8909355 Techniques for nerve stimulation 0 2012
8725271 Electrode device with elongated electrode 0 2013
 
ASTORA WOMEN'S HEALTH, LLC (12)
6862480 Pelvic disorder treatment device 97 2001
8195296 Apparatus for treating stress and urge incontinence 23 2006
* 2007/0260,288 Apparatus for treating stress and urge incontinence 24 2006
* 2009/0043,356 Electrode Sling for Treating Stress and Urge Incontinence 10 2007
8160710 Systems and methods for implanting tissue stimulation electrodes in the pelvic region 1 2007
8340786 Incontinence treatment device 11 2008
* 2008/0242,918 Incontinence Treatment Device 3 2008
9539433 Electrode implantation in a pelvic floor muscular structure 0 2009
8380312 Multi-zone stimulation implant system and method 0 2010
9427573 Deployable electrode lead anchor 0 2011
8774942 Tissue anchor 11 2012
9220887 Electrode lead including a deployable tissue anchor 0 2012
 
CYBERTRONICS, INC. (1)
9402550 Dynamic heart rate threshold for neurological event detection 0 2011
 
PACESETTER, INC. (5)
* 7123961 Stimulation of autonomic nerves 156 2004
7676275 Endovascular lead for chronic nerve stimulation 36 2005
* 7869869 Subcardiac threshold vagal nerve stimulation 23 2006
* 7813805 Subcardiac threshold vagal nerve stimulation 32 2006
* 8473068 Subcardiac threshold vagal nerve stimulation 2 2010
 
CYBERONCS, INC. (1)
8874229 Delivering scheduled and unscheduled therapy without detriment to battery life or accuracy of longevity predictions 0 2010
 
Catholic Healthcare West (11)
8615309 Microburst electrical stimulation of cranial nerves for the treatment of medical conditions 0 2007
8219188 Synchronization of vagus nerve stimulation with the cardiac cycle of a patient 11 2007
8150508 Vagus nerve stimulation method 11 2007
* 2007/0233,194 SYNCHRONIZATION OF VAGUS NERVE STIMULATION WITH THE CARDIAC CYCLE OF A PATIENT 36 2007
* 2007/0233,192 VAGUS NERVE STIMULATION METHOD 76 2007
8738126 Synchronization of vagus nerve stimulation with the cardiac cycle of a patient 2 2009
8660666 Microburst electrical stimulation of cranial nerves for the treatment of medical conditions 2 2009
8280505 Vagus nerve stimulation method 9 2009
* 2010/0063,563 MICROBURST ELECTRICAL STIMULATION OF CRANIAL NERVES FOR THE TREATMENT OF MEDICAL CONDITIONS 14 2009
* 2009/0177,252 SYNCHRONIZATION OF VAGUS NERVE STIMULATION WITH THE CARDIAC CYCLE OF A PATIENT 9 2009
* 2009/0171,405 VAGUS NERVE STIMULATION METHOD 16 2009
 
Brainsgate Ltd. (9)
7561919 SPG stimulation via the greater palatine canal 21 2006
* 2006/0287,677 SPG stimulation via the greater palatine canal 7 2006
8010189 SPG stimulation for treating complications of subarachnoid hemorrhage 5 2007
7908000 Transmucosal electrical stimulation 6 2007
* 2009/0131,739 EXTERNAL MAGNETIC FIELD STIMULATION OF THE SPG 8 2008
8954149 External stimulation of the SPG 3 2011
8406869 Post-acute electrical stimulation treatment of adverse cerebrovascular events 2 2011
8958881 Neuroprotective electrical stimulation 1 2013
9233245 SPG stimulation 0 2015
 
ZABARA, JACOB (1)
8700163 Cranial nerve stimulation for treatment of substance addiction 1 2005
 
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (8)
8914114 Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation 2 2004
* 2005/0125,044 Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation 92 2004
8729129 Neural tourniquet 5 2005
* 2005/0282,906 Neural tourniquet 16 2005
* 2008/0140,138 Inhibition of inflammatory cytokine production by stimulation of brain muscarinic receptors 14 2007
* 2009/0248,097 INHIBITION OF INFLAMMATORY CYTOKINE PRODUCTION BY CHOLINERGIC AGONISTS AND VAGUS NERVE STIMULATION 34 2008
8391970 Devices and methods for inhibiting granulocyte activation by neural stimulation 13 2008
9211409 Methods and systems for reducing inflammation by neuromodulation of T-cell activity 0 2009
 
RALSTON TECHNOLOGY GROUP, INC. (1)
* 2004/0153,436 Automated information management system and methods 17 2003
 
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (9)
* 7228167 Method and apparatus for detecting vagus nerve stimulation 51 2004
* 2004/0260,356 Method and apparatus for detecting vagus nerve stimulation 7 2004
* 2006/0020,298 Systems and methods for curbing appetite 43 2004
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* 2005/0273,060 Obesity treatment and device 143 2005
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8372158 Obesity treatment and device 8 2010
* 2011/0009,980 OBESITY TREATMENT AND DEVICE 4 2010
8911393 Obesity treatment and device 0 2013
 
GLOBALFOUNDRIES INC. (1)
9504390 Detecting, assessing and managing a risk of death in epilepsy 0 2013
 
NEUROSYSTEC CORPORATION (3)
* 2011/0077,579 Cochlear implant with localized fluid transport 13 2006
* 2008/0152,694 Devices, Systems and Methods for Ophthalmic Drug Delivery 25 2007
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AMS RESEARCH CORPORATION (3)
* 2005/0049,648 Pelvic disorder treatment device 19 2004
* 2009/0036,946 PELVIC DISORDER TREATMENTS 10 2008
* 2010/0217,340 Implantable Medical Device Connector System 2 2010
 
CVRX, INC. (29)
8086314 Devices and methods for cardiovascular reflex control 16 2002
7840271 Stimulus regimens for cardiovascular reflex control 70 2005
* 2005/0251,212 Stimulus regimens for cardiovascular reflex control 115 2005
* 2007/0021,794 Baroreflex Therapy for Disordered Breathing 54 2006
* 2007/0021,792 Baroreflex Modulation Based On Monitored Cardiovascular Parameter 98 2006
8290595 Method and apparatus for stimulation of baroreceptors in pulmonary artery 9 2006
8060206 Baroreflex modulation to gradually decrease blood pressure 21 2006
* 7813812 Baroreflex stimulator with integrated pressure sensor 40 2006
* 2007/0038,255 Baroreflex stimulator with integrated pressure sensor 69 2006
* 2007/0038,262 Baroreflex stimulation system to reduce hypertension 118 2006
8838246 Devices and methods for cardiovascular reflex treatments 2 2006
* 2007/0060,972 DEVICES AND METHODS FOR CARDIOVASCULAR REFLEX TREATMENTS 73 2006
8606359 System and method for sustained baroreflex stimulation 5 2007
* 2008/0215,111 Devices and Methods for Cardiovascular Reflex Control 10 2007
* 2008/0177,350 Expandable Stimulation Electrode with Integrated Pressure Sensor and Methods Related Thereto 21 2007
* 2008/0172,101 NON-LINEAR ELECTRODE ARRAY 52 2007
* 2008/0171,923 ASSESSING AUTONOMIC ACTIVITY USING BAROREFLEX ANALYSIS 30 2007
* 2008/0097,540 ECG INPUT TO IMPLANTABLE PULSE GENERATOR USING CAROTID SINUS LEADS 23 2007
* 2009/0234,418 DEVICES AND METHODS FOR CARDIOVASCULAR REFLEX CONTROL VIA COUPLED ELECTRODES 17 2009
7949400 Devices and methods for cardiovascular reflex control via coupled electrodes 16 2009
* 2010/0174,347 DEVICES AND METHODS FOR CARDIOVASCULAR REFLEX CONTROL VIA COUPLED ELECTRODES 11 2009
8583236 Devices and methods for cardiovascular reflex control 2 2010
* 2010/0179,614 DEVICES AND METHODS FOR CARDIOVASCULAR REFLEX CONTROL 6 2010
8718789 Electrode structures and methods for their use in cardiovascular reflex control 3 2010
* 2010/0249,874 BAROREFLEX THERAPY FOR DISORDERED BREATHING 5 2010
9044609 Electrode structures and methods for their use in cardiovascular reflex control 2 2011
8712531 Automatic baroreflex modulation responsive to adverse event 4 2012
8880190 Electrode structures and methods for their use in cardiovascular reflex control 2 2012
9427583 Electrode structures and methods for their use in cardiovascular reflex control 0 2015
 
NEUROVISTA CORPORATION (2)
* 2010/0023,089 Controlling a Subject's Susceptibility to a Seizure 29 2009
* 2010/0125,219 MINIMALLY INVASIVE SYSTEM FOR SELECTING PATIENT-SPECIFIC THERAPY PARAMETERS 55 2010
 
VENTURI GROUP, LLC (3)
* 2007/0073,354 Neural blocking therapy 62 2005
8798754 Neural blocking therapy 1 2008
* 2008/0154,333 NEURAL BLOCKING THERAPY 11 2008
 
Cardiac Pacemakers, Inc. (43)
7657312 Multi-site ventricular pacing therapy with parasympathetic stimulation 71 2003
* 2005/0096,705 Multi-site ventricular pacing therapy with parasympathetic stimulation 112 2003
8126560 Stimulation lead for stimulating the baroreceptors in the pulmonary artery 14 2003
8024050 Lead for stimulating the baroreceptors in the pulmonary artery 22 2003
7509166 Automatic baroreflex modulation responsive to adverse event 86 2003
* 2005/0149,155 Stimulation lead for stimulating the baroreceptors in the pulmonary artery 148 2003
* 2005/0149,156 Lead for stimulating the baroreceptors in the pulmonary artery 162 2003
* 2005/0149,129 Baropacing and cardiac pacing to control output 147 2003
8200331 System and method for filtering neural stimulation 11 2004
* 2006/0095,080 System and method for filtering neural stimulation 53 2004
8126559 Neural stimulation with avoidance of inappropriate stimulation 10 2004
* 2006/0116,737 Neural stimulation with avoidance of inappropriate stimulation 115 2004
7840266 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 40 2005
* 2006/0206,153 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 70 2005
7660628 System to provide myocardial and neural stimulation 64 2005
7881782 Neural stimulation system to prevent simultaneous energy discharges 14 2005
* 2006/0241,699 Neural stimulation system to prevent simultaneous energy discharges 52 2005
* 7570999 Implantable device for treating epilepsy and cardiac rhythm disorders 78 2005
* 2007/0142,871 Implantable device for treating epilepsy and cardiac rhythm disorders 95 2005
8131359 System and method to deliver therapy in presence of another therapy 7 2008
* 2008/0200,959 System and method to deliver therapy in presence of another therapy 14 2008
9314635 Automatic baroreflex modulation responsive to adverse event 1 2009
8131362 Combined neural stimulation and cardiac resynchronization therapy 30 2009
8200332 System and method for filtering neural stimulation 9 2009
8478397 System to provide myocardial and neural stimulation 1 2010
8406876 Closed loop neural stimulation synchronized to cardiac cycles 4 2010
8571655 Multi-site ventricular pacing therapy with parasympathetic stimulation 6 2010
9020595 Baroreflex activation therapy with conditional shut off 0 2010
8483823 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 0 2010
8548585 Concurrent therapy detection in implantable medical devices 2 2010
8929990 Transvascular neural stimulation device and method for treating hypertension 2 2010
8831718 Neural stimulation system to prevent simultaneous energy discharges 0 2011
8473076 Lead for stimulating the baroreceptors in the pulmonary artery 5 2011
8682434 Neural stimulation with avoidance of inappropriate stimulation 3 2012
8504149 System and method to deliver therapy in presence of another therapy 0 2012
8768462 System and method for filtering neural stimulation 0 2012
8660648 Implantable and rechargeable neural stimulator 1 2012
9211412 Closed loop neural stimulation synchronized to cardiac cycles 0 2013
* 8838239 Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 0 2013
8805494 System and method to deliver therapy in presence of another therapy 0 2013
9227068 Concurrent therapy detection in implantable medical devices 0 2013
9504836 System and method to deliver therapy in presence of another therapy 0 2014
* 9561373 System to stimulate a neural target and a heart 0 2016
 
EnteroMedics Inc. (42)
7489969 Vagal down-regulation obesity treatment 37 2003
* 2004/0176,812 Enteric rhythm management 159 2003
* 2004/0172,086 Nerve conduction block treatment 83 2003
* 2004/0172,085 Nerve stimulation and conduction block therapy 146 2003
7444183 Intraluminal electrode apparatus and method 109 2004
7167750 Obesity treatment with electrically induced vagal down regulation 238 2004
* 2004/0172,088 Intraluminal electrode apparatus and method 79 2004
* 2004/0167,583 Electrode band apparatus and method 59 2004
* 2005/0070,970 Movement disorder stimulation with neural block 89 2004
7844338 High frequency obesity treatment 34 2004
* 2005/0038,484 Controlled vagal blockage therapy 171 2004
7833279 Pancreatic exocrine secretion diversion apparatus and method 7 2004
* 2006/0106,332 Pancreatic exocrine secretion diversion apparatus and method 47 2004
7613515 High frequency vagal blockage therapy 53 2005
* 2005/0131,485 High frequency vagal blockage therapy 161 2005
7822486 Custom sized neural electrodes 37 2005
7672727 Neural electrode treatment 13 2005
* 2007/0043,411 Neural electrode 27 2005
* 2007/0043,400 Neural electrode treatment 42 2005
7986995 Bulimia treatment 13 2007
7720540 Pancreatitis treatment 13 2007
7693577 Irritable bowel syndrome treatment 13 2007
7630769 GI inflammatory disease treatment 17 2007
* 2007/0142,870 Irritable bowel syndrome treatment 36 2007
* 2007/0135,846 Vagal obesity treatment 46 2007
* 2007/0135,856 Bulimia treatment 37 2007
* 2007/0135,858 Pancreatitis treatment 35 2007
7729771 Nerve stimulation and blocking for treatment of gastrointestinal disorders 25 2007
* 2008/0021,512 Nerve stimulation and blocking for treatment of gastrointestinal disorders 79 2007
8103349 Neural electrode treatment 16 2009
8010204 Nerve blocking for treatment of gastrointestinal disorders 11 2010
8617095 Pancreatic exocrine secretion diversion apparatus and method 0 2010
8046085 Controlled vagal blockage therapy 23 2010
* 2011/0034,968 CONTROLLED VAGAL BLOCKAGE THERAPY 7 2010
8825164 Neural modulation devices and methods 0 2011
8369952 Bulimia treatment 4 2011
8538542 Nerve stimulation and blocking for treatment of gastrointestinal disorders 2 2011
8538533 Controlled vagal blockage therapy 1 2011
8862233 Electrode band system and methods of using the system to treat obesity 0 2013
9174040 Nerve stimulation and blocking for treatment of gastrointestinal disorders 0 2013
9162062 Controlled vagal blockage therapy 0 2013
9358395 Neural modulation devices and methods 1 2014
 
RAINBOW MEDICAL LTD. (1)
9370660 Independently-controlled bidirectional nerve stimulation 0 2014
 
BLUEWIND MEDICAL LTD. (3)
8755893 Tibial nerve stimulation 3 2012
9457186 Bilateral feedback 0 2014
9186504 Sleep apnea treatment 0 2014
 
KWALATA TRADING LIMITED (5)
8685724 In vitro techniques for use with stem cells 0 2005
* 2008/0220,466 In Vitro Techniques For Use With Stem Cells 5 2005
* 2006/0110,374 Method to accelerate stem cell recruitment and homing 11 2005
8541232 Composition comprising a progenitor/precursor cell population 1 2007
9234173 Regulating stem cells 0 2013
 
JAMES HARDIE TECHNOLOGY LIMITED (1)
* 2008/0096,018 Engineered low-density heterogeneous microparticles and methods and formulations for producing the microparticles 18 2006
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (37)
* 7860570 Implantable microstimulators and methods for unidirectional propagation of action potentials 142 2002
* 7292890 Vagus nerve stimulation via unidirectional propagation of action potentials 257 2002
* 7203548 Cavernous nerve stimulation via unidirectional propagation of action potentials 124 2002
* 2004/0015,205 Implantable microstimulators with programmable multielectrode configuration and uses thereof 232 2002
* 2004/0015,204 Implantable microstimulators and methods for unidirectional propagation of action potentials 157 2002
* 2003/0236,558 Vagus nerve stimulation via unidirectional propagation of action potentials 122 2002
* 2003/0236,557 Cavernous nerve stimulation via unidirectional propagation of action potentials 42 2002
7308303 Thrombolysis and chronic anticoagulation therapy 27 2002
* 2003/0083,698 Thrombolysis and chronic anticoagulation therapy 36 2002
7167751 Method of using a fully implantable miniature neurostimulator for vagus nerve stimulation 105 2004
7627383 Implantable stimulator 11 2005
7660631 Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction 9 2005
7801600 Controlling charge flow in the electrical stimulation of tissue 16 2005
* 2005/0240,229 Methods and systems for stimulation as a therapy for erectile dysfunction 72 2005
8175717 Ultracapacitor powered implantable pulse generator with dedicated power supply 24 2005
* 2007/0055,308 Ultracapacitor powered implantable pulse generator with dedicated power supply 46 2005
7729758 Magnetically coupled microstimulators 21 2005
* 2007/0123,938 Magnetically coupled microstimulators 33 2005
7890177 Device and therapy for erectile dysfunction and other sexual dysfunction 1 2006
7865243 Device and therapy for erectile dysfunction and other sexual dysfunction 2 2006
7801602 Controlling stimulation parameters of implanted tissue stimulators 14 2006
* 2006/0229,688 Controlling stimulation parameters of implanted tissue stimulators 54 2006
7899539 Cavernous nerve stimulation via unidirectional propagation of action potentials 22 2006
* 2007/0021,800 CAVERNOUS NERVE STIMULATION VIA UNIDIRECTIONAL PROPAGATION OF ACTION POTENTIALS 27 2006
* 2007/0083,240 Methods and systems for applying stimulation and sensing one or more indicators of cardiac activity with an implantable stimulator 23 2006
7877136 Enhancement of neural signal transmission through damaged neural tissue via hyperpolarizing electrical stimulation current 65 2007
7783362 Vagus nerve stimulation via unidirectional propagation of action potentials 10 2007
7877137 Thrombolysis and chronic anticoagulation therapy 0 2007
* 2008/0286,327 THOMBOLYSIS AND CHRONIC ANTICOAGULATION THERAPY 2 2007
8600512 Methods and systems for treating seizures caused by brain stimulation 0 2008
9393421 Controlling charge flow in the electrical stimulation of tissue 1 2010
* 2010/0280,575 CONTROLLING CHARGE FLOW IN THE ELECTRICAL STIMULATION OF TISSUE 1 2010
8548604 Implantable microstimulators and methods for unidirectional propagation of action potentials 1 2010
8712547 Cavernous nerve stimulation via unidirectional propagation of action potentials 0 2011
9409028 Implantable microstimulators with programmable multielectrode configuration and uses thereof 0 2012
9283394 Implantable microstimulators and methods for unidirectional propagation of action potentials 0 2013
9031656 Methods and systems for treating seizures caused by brain stimulation 0 2013
 
BIO NEURONICS CORPORATION (2)
8295934 Systems and methods of reducing artifact in neurological stimulation systems 1 2006
* 2008/0114,417 Systems and methods of reducing artifact in neurological stimulation systems 83 2006
 
Flunt Hills Scientific, LLC (1)
8945006 Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis 1 2014
 
NEVRO CORPORATION (60)
* 2009/0204,173 Multi-Frequency Neural Treatments and Associated Systems and Methods 101 2008
8255057 Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions 38 2009
8838248 Devices for controlling high frequency spinal cord modulation for inhibiting pain, and associated systems and methods, including simplified program selection 4 2010
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