Hybrid oligonucleotide phosphorothioates
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United States of America Patent
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Feb 12, 2002
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N/A
app pub date -
Mar 14, 2000
filing date -
Jul 23, 1992
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Abstract
The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.
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