Method for selectively purging CD77+ cells from bone marrow or peripheral blood
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United States of America Patent
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Feb 19, 2002
Issued Date -
N/A
app pub date -
Jul 31, 1998
filing date -
Feb 9, 1996
priority date (Note) -
Expired
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Abstract
A method for the selective purging ex vivo of CD77 positive cells from bone marrow or peripheral blood containing stem cells prior to autologous transplantation is described. The method involves treating the bone marrow or blood sample with shiga toxin or shiga-like toxin-1 to kill CD77.sup.+ cells or to remove them by affinity chromatography. The toxin selectively binds to CD77.sup.+ cells and not to other stem cells. The method offers a means for curing non-Hodgkin's lymphomas, myelomas and breast cancers expressing CD77.
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