Adhesive drug delivery composition
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United States of America Patent
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-
Mar 12, 2002
Issued Date -
N/A
app pub date -
Apr 28, 1994
filing date -
Nov 8, 1988
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Adhesive material from the fimbriae (esp. Type 1) of bacteria or synthetic analogues or fragments thereof is combined with a drug to provide for attachment to the gut of a mammal, thereby prolonging the transit time of the drug through the gut. The 28 kDa polypeptide from E. coli Type 1 fimbriae is the preferred adhesive material ('adhesin'). The drug is presented in a carrier such as albumin, a polylactide/glycolide copolymer or alginate microcapsules. The adhesin may be incorporated in the carrier during preparation thereof, adsorbed onto the carrier after preparation, or covalently linked thereto, for example with carbodiimide.
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