Poly(ethylene glycol) derivatives with proximal reactive groups
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United States of America Patent
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Mar 26, 2002
Grant Date -
Aug 2, 2001
app pub date -
Mar 11, 1999
filing date -
Mar 12, 1998
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Abstract
An activated, substantially water soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated poly(ethylene glycol) and the biologically active agent.
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