Osteoprotegerin
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United States of America Patent
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Apr 9, 2002
Issued Date -
N/A
app pub date -
Sep 3, 1996
filing date -
Dec 22, 1995
priority date (Note) -
Expired
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Abstract
The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
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