Closed antisense and sense oligonucleotides and their applications
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United States of America Patent
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Apr 9, 2002
Grant Date -
N/A
app pub date -
Nov 23, 1993
filing date -
Apr 25, 1991
priority date (Note) -
Expired
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Abstract
An antisense or sense agent of the oligonucleotide type, includes a single-stranded oligonucleotide sequence having a binding affinity for DNA, RNA, or protein selected from the group consisting of (a) a sequence whose ends are linked to one another via covalent linkage to form a closed, single-stranded structure, and (b) a sequence wherein one free end is linked to an internal nucleotide via covalent linkage to form a closed, single-stranded branched structure.
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