Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
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United States of America Patent
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Apr 16, 2002
Grant Date -
Aug 30, 2001
app pub date -
Nov 6, 1998
filing date -
Nov 6, 1998
priority date (Note) -
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Abstract
A biocompatible and biodegradable barrier material is applied to a tissue region, e.g., to seal a vascular puncture site. The barrier material comprises a compound, which is chemically cross-linked without use of an enzyme to form a non-liquid mechanical matrix. The compound preferably includes a protein comprising recombinant or natural serum albumin, which is mixed with a polymer that comprises poly(ethylene) glycol (PEG), and, most preferably, a multi-armed PEG polymer.
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