Modulation of human mast cell activation
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United States of America Patent
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Apr 16, 2002
Grant Date -
N/A
app pub date -
Dec 2, 1999
filing date -
Mar 25, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Human mast cell activation is modulated by ATP binding to P2-purinoceptors on the mast cell surface. ATP binding to the purinoceptors provides a target for therapeutic intervention for the treatment of disorders characterized by undesirable mast cell mediator release, such as asthma and allergy. Inhibitors of ATP binding to mast cell P2-purinoceptors are useful therapeutic agents for treatment of those disorders. Methods of treatment using such agents, and in vitro screening assays for selection of the therapeutic agents, are described.
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