Process for the manufacture of pharmaceutical composition with modified release of active principle comprising the matrix
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United States of America Patent
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Apr 23, 2002
Grant Date -
N/A
app pub date -
Nov 22, 2000
filing date -
Oct 1, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to a process for the manufacture of a pharmaceutical composition with modified release of active principle comprising at least one active principle, a lipid matrix agent composed of ester of alcohol with at least one fatty acid and at least one adjuvant. This process is characterized in that: a powder composed of at least one component selected in the group comprising the active principle and the adjuvant, is mixed, while heating and fluidizing, in order to obtain individual grains; the said lipid matrix agent is liquefied separately under warm conditions; the said powder is then coated under warm conditions by spraying the said lipid matrix agent over the individual grains; finally, the temperature of the combined product is lowered in order to allow the lipid matrix agent to solidify.
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