Control of immune responses by modulating activity of glycosyltransferases
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United States of America Patent
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Apr 23, 2002
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app pub date -
May 29, 1998
filing date -
May 30, 1997
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Abstract
The invention provides methods for inhibiting immune responses by inhibiting the biosynthesis of the sialyl galactosides that are involved in immune responses. In particular, B lymphocyte-mediated immune responses are mediated by interfering with synthesis of .alpha.2,6 sialylgalactosides, while T lymphocyte-mediated immune responses are inhibited by blocking synthesis of .alpha.2,3 sialylgalactosides. The inhibition is accomplished by, for example, inhibiting the activity of a glycosyltransferase involved in synthesis of the respective sialyl galactoside.
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