Evolution of whole cells and organisms by recursive sequence recombination
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United States of America Patent
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Apr 30, 2002
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Jul 15, 1999
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Jan 17, 1997
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Abstract
The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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