Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
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United States of America Patent
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May 7, 2002
Grant Date -
N/A
app pub date -
Apr 6, 1999
filing date -
Apr 6, 1999
priority date (Note) -
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Abstract
The present invention is directed to a pharmaceutical composition including a hydrophobic therapeutic agent having at least one ionizable functional group, and a carrier. The carrier includes an ionizing agent capable of ionizing the functional group, a surfactant, and optionally solubilizers, triglycerides, and neutralizing agents. The invention further relates to a method of preparing such compositions by providing a composition of an ionizable hydrophobic therapeutic agent, an ionizing agent, and a surfactant, and neutralizing a portion of the ionizing agent with a neutralizing agent. The compositions of the invention are particularly suitable for use in oral dosage forms.
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