Boron-mediated amidation of carboxylic acids
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United States of America Patent
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May 7, 2002
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N/A
app pub date -
Feb 5, 2001
filing date -
Feb 4, 2000
priority date (Note) -
Expired
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Abstract
The present invention provides an inexpensive one-step method for preparing an aromatic carboxamide, such as a phenyl substituted carboxamide) by reacting an aromatic amine (e.g. a phenylamine) and a carboxylic acid (e.g. an alkanoic acid or ester thereof) in the presence of a boron containing compound (e.g. boronic acid or boric acid) and, optionally, a chelating agent (e.g. a 2-pyridinylamine).
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