Derivatives of 6-(4-phenylbutoxy)hexylamine and process for producing Salmeterol
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United States of America Patent
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May 14, 2002
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app pub date -
Mar 28, 2001
filing date -
Sep 28, 1998
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Abstract
The present invention refers to new derivatives of the 6-(4-phenylbutoxy)hexylamine of the general formula (I): ##STR1## wherein: R.sub.1 is CHO or CHOR.sub.3 OR.sub.4, where R.sub.3 and R.sub.4 independently are C.sub.1 -C.sub.6 alkyl, aralkyl, or they form 5 or 6 membered cyclic acetals; and R.sub.2 is H, benzyl or an alkyloxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl or acyl group; and to a process for its obtention. The invention also refers to a new process for obtaining Salmeterol or its pharmaceutically acceptable salts, characterized in that reaction of an organometallic compound of the general formula (13) is carried out in an inert solvent at low temperature with a synthetic intermediate of the general formula (I), wherein R.sub.1 is CHO, and R.sub.2 is an alkyloxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl or acyl group.
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