Compositions and methods for treatment of Hepatitis C virus-associated diseases

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United States of America Patent

PATENT NO 6391542
SERIAL NO

08650093

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Antisense oligonucleotides are provided which are complementary to and hybridizable with at least a portion of HCV RNA and which are capable of inhibiting the function of the HCV RNA. These oligonucleotides can be administered to inhibit the activity of Hepatitis C virus in vivo or in vitro. These compounds can be used either prophylactically or therapeutically to reduce the severity of diseases associated with Hepatitis C virus, and for diagnosis and detection of HCV and HCV-associated diseases. Methods of using these compounds are also disclosed.

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Patent Owner(s)

Patent OwnerAddress
ISIS PHARMACEUTICALS INC1896 RUTHERFORD ROAD CARLSBAD CA 92008

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anderson, Kevin P Carlsbad, CA 23 820
Bruice, Thomas W Carlsbad, CA 16 835
Eto, Tatsuo Ohzu-machi, JP 4 237
Furasako, Shoji Tokyo, JP 1 74
Furukawa, Shinichi Koshi-machi, JP 22 352
Hamada, Fukusaburo Nishigoshi-machi, JP 13 375
Hanecak, Ronnie C San Clemente, CA 15 585
Hoshiko, Kazuya Kumamoto, JP 3 224
Lima, Walter F San Diego, CA 30 760
Nakatake, Hiroshi Kikuyo-machi, JP 29 444
Nishihara, Tsukasa Kumamoto, JP 8 246
Nozaki, Chikateru Kumamoto, JP 49 661

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