Method for evaluating the quality of comparisons between experimental and theoretical mass data
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United States of America Patent
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May 21, 2002
Grant Date -
N/A
app pub date -
Feb 19, 2000
filing date -
Feb 19, 2000
priority date (Note) -
Expired
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Abstract
A method for determining the probability that a biological molecule identification is incorrect for a chosen significance level is provided. The method includes comparing experimental mass data of an unknown biological molecule with theoretical mass data and calculating a score for each comparison; selecting at least two scores from the scores to form a primary data set; generating artificial data sets from the primary data set; calculating a sample mean for each artificial data set; estimating population mean and population standard deviation from the sample means wherein the population is based on the distribution underlying the primary dataset; computing a Z score from the population mean and population standard deviation for each score to standardize the scores; choosing a significance level; and comparing a test Z score to a Z score of the chosen significance level to determine the probability that the biological molecule identification is incorrect.
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