Matrices for drug delivery and methods for making and using the same
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United States of America Patent
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May 28, 2002
Grant Date -
N/A
app pub date -
Feb 14, 2000
filing date -
Feb 12, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-gels. In one embodiment, the enzyme L-amino acid decarboxylase is encapsulated and implanted in the brain to convert L-dopa to dopamine for treatment of Parkinson's disease.
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