High-affinity tryptophan transporter
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
May 28, 2002
Grant Date -
N/A
app pub date -
Dec 4, 1998
filing date -
Dec 5, 1997
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
A high affinity and extremely selective tryptophan transport system present in human monocyte-derived macrophages is disclosed. Human monocyte-derived macrophages include two distinct transporters, a high affinity (Km=290.+-.160 nM) transporter that is highly specific for tryptophan and a low affinity (Km=27.+-.4 .mu.M) transporter that is less specific for tryptophan, consistent with the known system L. The tryptophan transport system is predominantly (86%) sodium-independent. The high-affinity system is very specific for tryptophan and shows no transport of any other essential amino acids in the tryptophan transport concentration range. This high-affinity system is expressed at very low levels in fresh monocytes, but undergoes a 10-30 fold induction during macrophage differentiation. This high affinity, tryptophan-selective transport system allows macrophages to take up tryptophan efficiently under conditions of very low substrate concentration, such as can occur at sites of inflammation.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully