Acellular pertussis vaccines and methods of preparation thereof
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United States of America Patent
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Jun 4, 2002
Grant Date -
Jul 26, 2001
app pub date -
Jun 9, 1998
filing date -
May 4, 1995
priority date (Note) -
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Abstract
Acellular pertussis vaccines comprise purified toxin or toxoid thereof, filamentous haemagglutinin, pertactin and fimbrial agglutinogens formulated to confer protection to at least 70% of members of an at-risk population. The fimbrial agglutinogens may be prepared from a Bordetella strain, particularly a B. pertussis strain, by a multiple step procedure involving extraction of the fimbrial agglutinogens from cell paste and concentrating and purifying the extracted material.
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