Propofol formulation with enhanced microbial inhibition
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United States of America Patent
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Jun 4, 2002
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app pub date -
Dec 20, 2000
filing date -
Dec 20, 2000
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Abstract
A sterile, stable pharmaceutical formulations of oil-in-water emulsions of Propofol containing no preservative are provided that comprise optimal amounts of egg lecithin and soybean oil, with a suitable pH range to prevent significant growth of microorganisms for at least 24 hours after adventitious, extrinsic contamination. The lower pH in the formulation has shown the most antimicrobial activity. The reduced amount of fat in the formulation also allows chronic sedation over extended periods of time with a reduced chance of fat overload in the blood.
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