Erythronolide compounds
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United States of America Patent
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Jun 11, 2002
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N/A
app pub date -
Oct 28, 1999
filing date -
Oct 28, 1998
priority date (Note) -
Expired
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Abstract
Genetic engineering of the erythromycin polyketide synthase genes to effect combinatorial alterations of catalytic activities in the biosynthetic pathway can be used to generate a library of macrolides impractical to produce by chemical methods. The library includes examples of analogs with one, two and three altered carbon centers of the polyketide products.
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