Process for preparing polyvalent and physiologically degradable carbohydrate-containing polymers by enzymatic glycosylation reactions and the use thereof for preparing carbohydrate building blocks

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United States of America Patent

PATENT NO 6406894
SERIAL NO

08989136

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Abstract

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A process for preparing polyvalent, physiologically degradable carbohydrate-containing polymers by enzymatic glycosylation reactions is described. The carbohydrate-containing polymers thus prepared may be used for preparing carbohydrate building blocks. The polyvalent carbohydrate-containing polymers of the invention cause no intolerance reactions in vivo, either in their intact form or in the form of degradation products. The carbohydrate side chain of the carbohydrate-containing polymer is assembled by enzymatic glycosylation reactions in homogeneous aqueous buffer systems directly on a biodegradable polymer. The yields of the glycosylation reaction are significantly improved over known processes, and are often quantitative. This also provides a significant increase in the loading densities. A process for preparing free oligosaccharides by means of the carbohydrate-containing polymers of the invention is also described.

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GLYCOREX TRANSPLANTATION AB (PUBL)SOLVEGATAN 41 LUND 223 70

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ahlers, Michael Mainz, DE 36 560
Bartnik, Eckart Wiesbaden, DE 21 358
Hoersch, Brigitte Kriftel, DE 3 7
Kretzschmar, Gerhard Eschborn, DE 31 763
Seiffge, Dick Mainz-Kostheim, DE 1 2

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