Method reagent and kit for the detection of fecal occult blood
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United States of America Patent
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Jun 25, 2002
Issued Date -
N/A
app pub date -
May 12, 1995
filing date -
Sep 14, 1993
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Abstract
A fecal specimen may be tested for the presence of occult blood by combining the fecal specimen with (a) an oxidizable substrate that produces a colored product in the presence of peroxide and hemoglobin; (b) hydrogen peroxide or a peroxide source; and (c) an enhancer selected to enhance the sensitivity of the test. Suitable enhancers are monocyclic nitrogen-containing aromatic heterocyclic compounds; tertiary or quaternary ammonium compounds having a phenyl, hydroxy alkyl or esterified hydroxy alkyl attached to the nitrogen; or quinoline or a substituted derivative thereof. If hemoglobin is present in the fecal sample, the oxidizable substrate is converted to the visibly detectable, colored product.
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