Nuclear factors associated with transcriptional regulation

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United States of America Patent

PATENT NO 6410516
SERIAL NO

08464364

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Abstract

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Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription can be isolated and employed to enhance transription of Ig genes. In particular, NF-kB, the gene encoding NF-kB, IkB and the gene encoding IkB and uses therefor.

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Patent Owner(s)

Patent OwnerAddress
PRESIDENT & FELLOWS OF HARVARD COLLEGE17 QUINCY STREET CAMBRIDGE MA 02138

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baeuerle, Patrick A Eichenau, DE 10 227
Baldwin, Jr Albert S Chapel Hill, NC 6 181
Baltimore, David New York, NY 90 1786
Clerc, Roger G Binningen, CH 9 182
Corcoran, Lynn M Port Melbourne, AU 5 173
Fan, Chen-Ming San Francisco, MA 8 209
Lebowitz, Jonathan H Zionsville, IN 16 658
Lenardo, Michael J Potomac, MD 17 235
Maniatis, Thomas P Belmont, MA 8 266
Sen, Ranjan Cambridge, MA 10 215
Sharp, Phillip A Newton, MA 45 2605
Singh, Harinder Chicago, IL 25 457
Staudt, Louis Silver Springs, MD 5 173

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