Peptides and methods against psoriasis
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United States of America Patent
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Jul 2, 2002
Issued Date -
N/A
app pub date -
Jan 14, 1994
filing date -
Mar 21, 1989
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
This invention relates to methods of preventing or reducing the severity of psoriasis. In one embodiment, the method involves administering to the individual a peptide having substantially the sequence of a non-conserved region sequence of a T cell receptor, present on the surface of T cells mediating psoriasis or a fragment thereof, wherein the peptide or fragment is capable of causing an effect on the immune system to regulate the T cells. In particular, the T cell receptor has the V.beta. region-V.beta.3, V.beta.13.1 or V.beta.17. In another embodiment, the method involves gene therapy. The invention also relates to methods of diagnosing psoriasis by determining the presence of psoriasis predominant T cell receptors.
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