US Patent No: 6,414,018
Number of patents in Portfolio can not be more than 2000
Compositions, apparatus and methods for facilitating surgical procedures
Stats
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Jul 2, 2002
Issued date -
Jan 28, 2000
filing date -
09/494,145
serial no -
In Force
status
Importance
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Abstract
Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a .beta.-blocker are provided, wherein the .beta.-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques. Methods for performing a surgical procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. The heart then is electrically paced using an electrical pacing system, thereby to maintain the patient's blood circulation. The electrical pacing then is selectively intermittently stopped to allow ventricular asystole to occur, and the steps of the surgical or therapeutic procedure, such as suturing, are conducted during the time that the electrical pacing is intermittently stopped. The methods and compositions advantageously may be used in a range of different surgical procedures including cardiac, vascular and neurosurgical procedures.
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First Claim
Related Publications
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
|---|---|---|---|
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| 5,452,733 Methods for performing thoracoscopic coronary artery bypass | 622 | 1993 | |
| 5,433,700 Method for intraluminally inducing cardioplegic arrest and catheter for use therein | 179 | 1993 | |
| 5,425,705 Thoracoscopic devices and methods for arresting the heart | 228 | 1993 | |
| 5,458,574 System for performing a cardiac procedure | 298 | 1994 | |
| 5,558,644 Retrograde delivery catheter and method for inducing cardioplegic arrest | 180 | 1995 | |
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| 4,771,777 Perfusion type balloon dilatation catheter, apparatus and method | 346 | 1987 | |
| 5,320,604 Low-profile single-lumen dual-balloon catheter with integrated guide wire for embolectomy dilatation/occlusion and delivery of treatment fluid | 110 | 1993 | |
|
|
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| 5,443,489 Apparatus and method for ablation | 342 | 1994 | |
| 5,738,096 Cardiac electromechanics | 344 | 1996 | |
|
|
|||
| 4,962,095 Method of reducing pre-and post-ischemic myocardial arrhythmias and fibrillation | 20 | 1989 | |
| 5,116,851 Pharmaceutical composition and method for treating cardiovascular diseases using substituted anilides and sulfonamides | 8 | 1990 | |
|
|
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| 4,736,024 Process for preparing salt of hyaluronic acid with a pharmaceutically active substance | 73 | 1986 | |
| 5,442,053 Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions | 69 | 1992 | |
|
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| 5,651,378 Method of using vagal nerve stimulation in surgery | 179 | 1996 | |
| 5,913,876 Method and apparatus for using vagus nerve stimulation in surgery | 160 | 1997 | |
|
|
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| 5,139,789 Cardioplegia solutions that prevent heart cell swelling | 9 | 1990 | |
| 5,428,039 Method for electively achieving reversible hyperpolarized cardiac arrest | 20 | 1994 | |
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|
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| 4,562,596 Aortic graft, device and method for performing an intraluminal abdominal aortic aneurysm repair | 338 | 1984 | |
| 5,591,195 Apparatus and method for engrafting a blood vessel | 244 | 1995 | |
|
|
|||
| 5,182,102 Anti-glaucoma compositions | 11 | 1991 | |
|
|
|||
| 4,857,552 Stable pharmaceutical composition | 9 | 1988 | |
|
|
|||
| 5,096,929 2-amino-1,2,3,4-tetrahydronaphthalene derivatives with cardiovascular activity, process for their preparation and pharmaceutical compositions containing them | 7 | 1990 | |
|
|
|||
| 4,605,399 Transdermal infusion device | 207 | 1984 | |
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|
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| 5,634,895 Apparatus and method for transpericardial delivery of fluid | 81 | 1995 | |
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| 4,404,971 Dual balloon catheter | 85 | 1981 | |
|
|
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| 5,176,638 Regional perfusion catheter with improved drug delivery control | 105 | 1991 | |
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| 5,455,229 Method for minimizing and containing ischemic and reperfusion injury | 13 | 1992 | |
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| 5,478,309 Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery | 344 | 1994 | |
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| 5,735,290 Methods and systems for performing thoracoscopic coronary bypass and other procedures | 282 | 1994 | |
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| 4,935,004 Peritoneal dialysis catheter | 58 | 1989 | |
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|
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| 4,923,457 Artificial gland for implantation in a human body | 15 | 1986 | |
|
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| 4,248,214 Illuminated urethral catheter | 85 | 1979 | |
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|
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| 4,827,906 Apparatus and method for activating a pump in response to optical signals from a pacemaker | 43 | 1988 | |
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|
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| 5,593,428 Emergency external cardiac defibrillator and pacing method and apparatus | 11 | 1993 | |
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| 4,445,892 Dual balloon catheter device | 500 | 1982 | |
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| 4,230,119 Micro-hemostat | 119 | 1978 | |
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| 4,581,017 Catheter systems | 410 | 1983 | |
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| 5,356,427 Catheter for temporary pacing and pacemaker | 17 | 1993 | |
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| 5,474,783 Solubility parameter based drug delivery system and method for altering drug saturation concentration | 107 | 1991 | |
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| 5,095,903 Epi-cardial electrode with an incorporated cardiac radio-frequency receiver (C&R) for temporary heart stimulation from the outside, prearranged for permanent stimulation | 20 | 1989 | |
|
|
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| 5,543,419 Quinuclidine esters process and intermediate for their preparation and pharmaceutical compositions containing them | 7 | 1994 | |
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| 5,124,326 Pharmaceutically efficacious pteridine derivatives | 7 | 1990 | |
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| 4,377,704 Hetero-prostaglandin derivatives and processes for preparing them | 7 | 1981 | |
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| 4,573,966 Method and apparatus for removing and/or enlarging constricted areas in vessels conducting body fluids | 287 | 1982 | |
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| 5,506,229 Methods of treatment using ranolazine and related piperazine derivatives | 31 | 1992 | |
|
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| 5,152,277 Catheter tube | 105 | 1990 | |
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| 5,083,564 Method for alleviating and diagnosing symptoms of heart block | 88 | 1990 | |
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| 5,290,766 Cardioplegic compositions | 18 | 1992 | |
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|
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| 5,162,374 Method for reversibly arresting muscle activity | 10 | 1991 | |
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|
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| 4,673,563 Adenosine in the treatment of supraventricular tachycardia | 66 | 1985 | |
|
|
|||
| 4,309,776 Intravascular implantation device and method of using the same | 83 | 1980 | |
| 4,661,509 Methods for treating leukopenia | 30 | 1984 | |
| 5,087,243 Myocardial iontophoresis | 277 | 1990 | |
| 5,229,127 Rapid miosis with control of intraocular pressure using a mixture of a cetylcholine and carbachol derivatives | 17 | 1990 | |
| 5,287,861 Coronary artery by-pass method and associated catheter | 326 | 1992 | |
| 5,459,140 Combination preparation based on dipivalylepinephrine (DPE) for reducing intraocular pressure | 7 | 1993 | |
| 5,312,344 Arterial perfusion cannula for extracorporeal circulation and other uses | 130 | 1993 | |
| 5,873,366 Method for transmyocardial revascularization | 37 | 1996 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jan 2, 2014 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |