Peptide nucleic acids having 2,6-diaminopurine nucleobases
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United States of America Patent
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Jul 2, 2002
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N/A
app pub date -
Jul 24, 1996
filing date -
May 24, 1991
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Expired
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Abstract
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C.sub.1 -C.sub.8 alkylamine side chains.
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