Alpha-and beta-substituted trifluoromethyl ketones as phospholipase inhibitors

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United States of America Patent

PATENT NO 6414179
APP PUB NO 20020065246A1
SERIAL NO

09816574

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Inhibitors of the cytosolic phospholipase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula ##STR1## where X, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.a and R.sup.b are as defined in the specification.

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Patent Owner(s)

  • BRISTOL-MYERS SQUIBB COMPANY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Balasubramanian, Neelakantan Madison, CT 19 192
Banville, Jacques St-Hubert, CA 27 258
Gai, Yonghua Killingworth, CT 46 759
Marinier, Anne Kirkland, CA 26 198
Plamondon, Serge Ste-Catherine, CA 10 128
Roy, Stephan St-Lambert, CA 8 130

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