Medical device and production method thereof
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United States of America Patent
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Jul 9, 2002
Issued Date -
N/A
app pub date -
Jul 27, 2000
filing date -
Jun 4, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A medical device and production method therefor which can retain antimicrobial activity for a prolonged period of time under physiological indwelling conditions and also having a physiologically active function. The production method is independent of the kind of base material selected for the medical device. The antimicrobial medical device having physiological activity comprises a cross-linked coating film constituting a high molecular weight substance having acid anhydride groups formed on a surface of a base material. The cross-linked coating film is formed by reacting preferably from 0.5 to 10 mol % of the acid anhydride groups contained in the high molecular weight substance with a compound having two or more active hydrogen atoms in one molecule. Also, a physiologically active substance and an antimicrobial substance are bonded to the cross-linked coating film.
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