US Patent No: 6,416,786

Number of patents in Portfolio can not be more than 2000

Sustained release tablet containing hydrocolloid and cellulose ether

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ATTORNEY / AGENT: (SPONSORED)

Importance

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Abstract

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The present invention is directed to a solid sustained release pharmaceutical tablet for administering to a host, comprising a therapeutically effective amount of a pharmaceutically active ingredient and a sustained release carrier therefor, said sustained release carrier comprising (a) a hydrocolloid selected from the group consisting of xanthan gum, guar gum, and alginic acid or a pharmaceutically acceptable salt thereof, and (b) a cellulose ether, said hydrocolloid and cellulose ether being present in synergistic effective amounts to retard release of said pharmaceutically active ingredient, said hydrocolloid being present in amount ranging from about 0.3% to about 7.0% by weight of the tablet and said cellulose ether being present in an amount ranging from 3% to about 20% of said tablet, and said cellulose ether being present in said carrier in amounts equal to or greater than 33% by weight and said carrier being present in amounts less than 35% by weight of said tablet.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
NOSTRUM PHARMACEUTICALS, INC.PRINCETON, NJ10

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Inamdar, Kavita Mumbai, IN 2 5
Mulye, Nirmal Long Beach, NY 22 176

Cited Art Landscape

Patent Info (Count) # Cites Year
 
PHARMACIA & UPJOHN AB (1)
5,804,217 Manufacturing matrices 1 1995
 
Other [Check patent profile for assignment information] (3)
4,775,535 Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics 22 1986
4,832,956 Disintegrating tablet and process for its preparation 48 1987
4,855,143 Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics 21 1988
 
EURAND INTERNATIONAL S.P.A. (1)
* 5,047,248 Formulation for preparing sustained release drugs for oral administration 30 1989
 
ALZA CORPORATION (2)
5,006,346 Delivery system 20 1989
5,338,550 Stereoisomer therapy 7 1992
 
PENWEST PHARMACEUTICALS COMPANY (14)
4,994,276 Directly compressible sustained release excipient 70 1988
5,128,143 Sustained release excipient and tablet formulation 64 1990
5,135,757 Compressible sustained release solid dosage forms 46 1991
* 5,169,639 Controlled release verapamil tablets 34 1991
5,472,711 Agglomerated hydrophilic complexes with multi-phasic release characteristics 38 1992
5,478,574 Agglomerated hydrophilic complexes with multi-phasic release characteristics 28 1993
5,612,053 Controlled release insufflation carrier for medicaments 86 1995
5,512,297 Sustained release heterodisperse hydrogel systems for insoluble drugs 33 1995
5,554,387 Sustained release heterodisperse hydrogel systems for insoluble drugs 29 1995
5,773,025 Sustained release heterodisperse hydrogel systems--amorphous drugs 65 1996
5,667,801 Sustained release heterodisperse hydrogel systems for insoluble drugs 21 1996
5,670,168 Agglomerated hydrophilic complexes with multi-phasic release characteristics 29 1996
5,738,865 Controlled release insufflation carrier for medicaments 116 1996
5,846,563 Sustained release heterodisperse hydrogel systems for insoluble drugs 23 1997
 
Advanced Technology Pharmaceuticals Corporation (2)
5,292,534 Sustained release composition and method utilizing xanthan gum and an active ingredient 34 1992
5,427,799 Sustained release composition and method utilizing xanthan gum and an active ingredient 23 1993
 
EURO-CELTIQUE S.A. (1)
5,811,126 Controlled release matrix for pharmaceuticals 83 1995
 
ANDA SR PHARMACEUTICALS ICN. (1)
5,419,917 Controlled release hydrogel formulation 38 1994
 
FUJISAWA PHARMACEUTICAL CO., LTD. (1)
4,695,467 Sustained release tablet 57 1985
 
THE DOW CHEMICAL COMPANY (2)
4,734,285 Sustained release compositions 38 1985
4,704,285 Sustained release compositions comprising hydroxypropyl cellulose ethers 64 1985
 
Bend Research, Inc. (1)
5,876,752 Use of interfacially-polymerized membranes in delivery devices 14 1993
 
Ethical Pharmaceuticals Limited (1)
4,880,830 Slow release formulation 47 1987
 
PAUL ROYALTY FUND, L.P. (2)
5,464,633 Pharmaceutical tablets releasing the active substance after a definite period of time 78 1994
5,780,057 Pharmaceutical tablet characterized by a showing high volume increase when coming into contact with biological fluids 76 1997
 
ENDO PHARMACEUTICALS INC. (2)
5,455,046 Sustained release heterodisperse hydrogel systems for insoluble drugs 52 1993
5,662,933 Controlled release formulation (albuterol) 36 1995
 
E. R. Squibb & Sons, Inc. (2)
4,610,870 Controlled release formulation 89 1984
4,792,452 Controlled release formulation 106 1987
 
Plastic Dress-Up Co. (1)
5,895,663 Pseudoephedrine hydrochloride extended-release tablets 20 1997
 
RECKITT BENCKISER HEALTHCARE (UK) LIMITED (1)
5,415,871 Therapeutic agents 36 1991
 
BIOVAIL TECHNOLOGIES LTD. (1)
5,851,555 Controlled release dosage forms containing water soluble drugs 22 1997
 
WARNER-LAMBERT COMPANY (2)
4,973,470 Sustained release pharmaceutical compositions 5 1989
5,077,051 Sustained release of active agents from bioadhesive microcapsules 31 1990
 
The Procter & Gamble Company (1)
4,786,518 Iron mineral supplements 34 1987
 
FOREST LABORATORIES, INC. (2)
4,369,172 Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose 229 1981
4,795,327 Controlled release solid drug dosage forms based on mixtures of water soluble nonionic cellulose ethers and anionic surfactants 39 1984
 
BRITISH TECHNOLOGY GROUP LIMITED (1)
5,063,205 Uptake of iron by the body 5 1987
 
WYETH (1)
4,966,768 Sustained release etodolac 28 1988
 
SHIN-ETSU CHEMICAL CO., LTD. (1)
5,372,998 Powdery material for preparing drug-coating solution 5 1993
 
FIRST NATIONAL BANK OF GRAPEVINE (1)
5,002,774 Sustained release pharmaceutical tablet 27 1989
 
GATX VENTURES, INC. (1)
5,582,837 Alkyl-substituted cellulose-based sustained-release oral drug dosage forms 103 1995
 
DAEWON PHARM., CO., LTD (1)
5,700,832 Antianemic agent containing iron and difructose 4 1995
 
NOVARTIS CONSUMER HEALTH, INC. (1)
4,752,479 Multi vitamin and mineral dietary supplement with controlled release bioavailable iron 64 1986
 
VERLA-PHARM ARZNEIMITTELFABRIK APOTHEKER H.J.V. EHRLICH GMBH & CO. KG (1)
5,143,732 Orally administered pharmaceutical agent for iron and magnesium substitutive therapy 3 1989
 
LABOPHARM INC. (1)
5,885,615 Pharmaceutical controlled release tablets containing a carrier made of cross-linked amylose and hydroxypropylmethylcellulose 13 1996
 
Egis Gyogyszergyar Rt. (1)
5,543,155 Diffusion-osmotic controlled drug-release pharmaceutical composition and process for preparing same 33 1994
 
Sterling Drug Inc. (1)
5,223,268 Low solubility drug-coated bead compositions 18 1991
 
APR APPLIED PHARMA RESEARCH SA (1)
5,681,583 Multilayered controlled-release oral solid pharmaceutical forms 76 1995
 
J. RETTENMAIER & SOEHNE GMBH + CO. KG (2)
5,741,524 Sustained-release formulations utilizing pharmaceutical excipient having improved compressibility 83 1996
5,858,412 Sustained release formulations utilizing pharmaceutical excipient having improved compressibility with modified microcrystalline 71 1997
 
BASF AKTIENGESELLSCHAFT (1)
5,741,519 The production of active substance compositions in the form of a solid solution of the active substance in a polymer matrix, and active substance compositions produced by this process 37 1996
 
ZYMA SA (1)
4,882,169 Swellable pellets 31 1988
 
TCF NATIONAL BANK (1)
5,126,145 Controlled release tablet containing water soluble medicament 115 1990
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
ETHYPHARM (1)
8,029,825 Low-dose tablets having a network of polymers 0 2004
 
TRANSFORM PHARMACEUTICALS, INC. (1)
* 2004/0106,098 Analysis of pharmaceutical solubility and stability 12 2003
 
HANMI PHARM. CO., LTD. (2)
* 7,704,526 Sustained release composition for oral administration of drugs 2 2003
* 2004/0081,693 Sustained release composition for oral administration of drugs 2 2003
 
VIRUN, INC. (2)
8,765,661 Compositions containing non-polar compounds 0 2009
8,282,977 Compositions containing non-polar compounds 3 2009
 
BASF AKTIENGESELLSCHAFT (1)
* 6,638,619 Method for producing a granulate from a melt 1 2002
 
Nostrum Pharmaceuticals, Inc. (2)
* 2004/0224,017 Process for preparing sustained release tablets 14 2004
* 2011/0071,137 PROCESS FOR PREPARING SUSTAINED RELEASE TABLETS 0 2010
* Cited By Examiner