US Patent No: 6,416,786
Number of patents in Portfolio can not be more than 2000
Sustained release tablet containing hydrocolloid and cellulose ether
Stats
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Jul 9, 2002
Issued date -
Dec 10, 1999
filing date -
09/459,300
serial no -
In Force
status
Importance
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Abstract
The present invention is directed to a solid sustained release pharmaceutical tablet for administering to a host, comprising a therapeutically effective amount of a pharmaceutically active ingredient and a sustained release carrier therefor, said sustained release carrier comprising (a) a hydrocolloid selected from the group consisting of xanthan gum, guar gum, and alginic acid or a pharmaceutically acceptable salt thereof, and (b) a cellulose ether, said hydrocolloid and cellulose ether being present in synergistic effective amounts to retard release of said pharmaceutically active ingredient, said hydrocolloid being present in amount ranging from about 0.3% to about 7.0% by weight of the tablet and said cellulose ether being present in an amount ranging from 3% to about 20% of said tablet, and said cellulose ether being present in said carrier in amounts equal to or greater than 33% by weight and said carrier being present in amounts less than 35% by weight of said tablet.
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First Claim
Related Publications
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 4,994,276 Directly compressible sustained release excipient | 69 | 1988 | |
| 5,128,143 Sustained release excipient and tablet formulation | 63 | 1990 | |
| 5,135,757 Compressible sustained release solid dosage forms | 43 | 1991 | |
| 5,169,639 Controlled release verapamil tablets | 33 | 1991 | |
| 5,472,711 Agglomerated hydrophilic complexes with multi-phasic release characteristics | 31 | 1992 | |
| 5,478,574 Agglomerated hydrophilic complexes with multi-phasic release characteristics | 27 | 1993 | |
| 5,612,053 Controlled release insufflation carrier for medicaments | 74 | 1995 | |
| 5,512,297 Sustained release heterodisperse hydrogel systems for insoluble drugs | 32 | 1995 | |
| 5,554,387 Sustained release heterodisperse hydrogel systems for insoluble drugs | 28 | 1995 | |
| 5,773,025 Sustained release heterodisperse hydrogel systems--amorphous drugs | 54 | 1996 | |
| 5,667,801 Sustained release heterodisperse hydrogel systems for insoluble drugs | 20 | 1996 | |
| 5,670,168 Agglomerated hydrophilic complexes with multi-phasic release characteristics | 22 | 1996 | |
| 5,738,865 Controlled release insufflation carrier for medicaments | 109 | 1996 | |
| 5,846,563 Sustained release heterodisperse hydrogel systems for insoluble drugs | 20 | 1997 | |
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| 5,292,534 Sustained release composition and method utilizing xanthan gum and an active ingredient | 29 | 1992 | |
| 5,427,799 Sustained release composition and method utilizing xanthan gum and an active ingredient | 20 | 1993 | |
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| 5,006,346 Delivery system | 17 | 1989 | |
| 5,338,550 Stereoisomer therapy | 7 | 1992 | |
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| 4,610,870 Controlled release formulation | 71 | 1984 | |
| 4,792,452 Controlled release formulation | 88 | 1987 | |
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| 5,455,046 Sustained release heterodisperse hydrogel systems for insoluble drugs | 47 | 1993 | |
| 5,662,933 Controlled release formulation (albuterol) | 35 | 1995 | |
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| 4,369,172 Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose | 212 | 1981 | |
| 4,795,327 Controlled release solid drug dosage forms based on mixtures of water soluble nonionic cellulose ethers and anionic surfactants | 31 | 1984 | |
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| 5,741,524 Sustained-release formulations utilizing pharmaceutical excipient having improved compressibility | 53 | 1996 | |
| 5,858,412 Sustained release formulations utilizing pharmaceutical excipient having improved compressibility with modified microcrystalline | 57 | 1997 | |
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| 5,464,633 Pharmaceutical tablets releasing the active substance after a definite period of time | 69 | 1994 | |
| 5,780,057 Pharmaceutical tablet characterized by a showing high volume increase when coming into contact with biological fluids | 63 | 1997 | |
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| 4,734,285 Sustained release compositions | 36 | 1985 | |
| 4,704,285 Sustained release compositions comprising hydroxypropyl cellulose ethers | 57 | 1985 | |
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| 4,973,470 Sustained release pharmaceutical compositions | 5 | 1989 | |
| 5,077,051 Sustained release of active agents from bioadhesive microcapsules | 27 | 1990 | |
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| 5,419,917 Controlled release hydrogel formulation | 28 | 1994 | |
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| 5,681,583 Multilayered controlled-release oral solid pharmaceutical forms | 59 | 1995 | |
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| 5,741,519 The production of active substance compositions in the form of a solid solution of the active substance in a polymer matrix, and active substance compositions produced by this process | 30 | 1996 | |
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| 5,876,752 Use of interfacially-polymerized membranes in delivery devices | 12 | 1993 | |
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| 5,851,555 Controlled release dosage forms containing water soluble drugs | 13 | 1997 | |
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| 5,063,205 Uptake of iron by the body | 5 | 1987 | |
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| 5,700,832 Antianemic agent containing iron and difructose | 2 | 1995 | |
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| 5,543,155 Diffusion-osmotic controlled drug-release pharmaceutical composition and process for preparing same | 28 | 1994 | |
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| 4,880,830 Slow release formulation | 45 | 1987 | |
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| 5,047,248 Formulation for preparing sustained release drugs for oral administration | 27 | 1989 | |
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| 5,811,126 Controlled release matrix for pharmaceuticals | 50 | 1995 | |
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| 5,002,774 Sustained release pharmaceutical tablet | 15 | 1989 | |
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| 4,695,467 Sustained release tablet | 57 | 1985 | |
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| 5,582,837 Alkyl-substituted cellulose-based sustained-release oral drug dosage forms | 83 | 1995 | |
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| 5,885,615 Pharmaceutical controlled release tablets containing a carrier made of cross-linked amylose and hydroxypropylmethylcellulose | 7 | 1996 | |
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| 4,752,479 Multi vitamin and mineral dietary supplement with controlled release bioavailable iron | 59 | 1986 | |
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| 5,804,217 Manufacturing matrices | 1 | 1995 | |
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| 5,895,663 Pseudoephedrine hydrochloride extended-release tablets | 12 | 1997 | |
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| 5,415,871 Therapeutic agents | 29 | 1991 | |
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| 5,372,998 Powdery material for preparing drug-coating solution | 5 | 1993 | |
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| 5,223,268 Low solubility drug-coated bead compositions | 17 | 1991 | |
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| 5,126,145 Controlled release tablet containing water soluble medicament | 97 | 1990 | |
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| 4,786,518 Iron mineral supplements | 32 | 1987 | |
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| 5,143,732 Orally administered pharmaceutical agent for iron and magnesium substitutive therapy | 3 | 1989 | |
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| 4,966,768 Sustained release etodolac | 24 | 1988 | |
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| 4,882,169 Swellable pellets | 30 | 1988 | |
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| 4,775,535 Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics | 22 | 1986 | |
| 4,832,956 Disintegrating tablet and process for its preparation | 40 | 1987 | |
| 4,855,143 Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics | 21 | 1988 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jan 9, 2014 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |