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Abstract

A strong, thin flexible mineralized collagen membrane is disclosed that is useful for such medical applications as a barrier for guided tissue regeneration, periodontal defect repair, bone grafts and skin wound repair. The mineralized collagen membrane comprises a substantially homogeneous mineralized collagen composite consisting essentially of about 30% to about 70% by weight of a collagen component and about 30% to about 70% by weight of a calcium phosphate minerals component precipitated from a collagen slurry by a soluble calcium ion-containing solution and a soluble phosphate ion-containing solution. The calcium phosphate minerals component has a mole ratio of calcium to phosphate in the range of about 1.0 to about 2.0. The thin mineralized collagen membrane has a bulk density of the membrane of at least about 1.0 g/cm.sup.3 and has a thickness not greater than about 0.5 mm and preferably not greater than about 0.3 mm. A corresponding method of making the mineralized collagen membrane includes casting washed mineralized collagen slurry as a thin, flat sheet onto a surface, such as a sieve or filter paper, air drying the sheet and removing it from the surface as the thin mineralized collagen membrane.

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First Claim