Malaria merozoite antigen subunit vaccine
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United States of America Patent
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Jul 9, 2002
Grant Date -
N/A
app pub date -
Oct 7, 1996
filing date -
Feb 4, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An immunogenic polypeptide for use in inducing an immune response against Plasmodium infection comprises an amino acid sequence corresponding to a non-full length fragment of the apical membrane antigen 1 (AMA-1) of Plasmodium species which does not include a transmembrane domain thereof, and which is stabilised by folding thereof. Production of the immunogenic polypeptide by expression of a recombinant DNA molecule in a host cell, and methods and compositions using the immunogenic polypeptide are disclosed.
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