Cross-linked high amylose starch having functional groups as a matrix for the slow release of pharmaceutical agents
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United States of America Patent
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Jul 16, 2002
Issued Date -
N/A
app pub date -
Feb 24, 1999
filing date -
Feb 24, 1998
priority date (Note) -
Expired
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Abstract
The present invention relates to a solid slow release oral pharmaceutical dosage unit resistant to amylase which comprises a solid dosage unit made up of an admixture of a therapeutic dosage of an orally effective pharmaceutical agent, an optional polysaccharide or polyol, and high amylose starch, wherein the cross-linking of the high amylose starch has been carried out with a cross-linking agent with from about 0.1 g to about 40 g of cross-linking agent per 100 g of high amylose starch. In a preferred embodiment of the invention, the high amylose starch is modified with a functional group-attaching reagent that covalently bonds functional groups thereto.
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