Use of fluorescein aryl ethers in high throughput cytochrome P450 inhibition assays
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United States of America Patent
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Jul 16, 2002
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app pub date -
Aug 10, 2000
filing date -
Aug 19, 1999
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Abstract
Novel fluorescent substrates of human cytochrome P450 enzymes are provided. Also provided are methods for their manufacture and use. These substrates are useful in assessing cytochrome P450 enzyme activity and in selecting compounds which inhibit cytochrome P450 enzyme activity and, in particular, for identifying potential adverse drug interactions which are mediated by inhibition of cytochrome P450 enzyme activity.
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