PRODUCTION OF MULTIMERIC PROTEIN BY CELL FUSION METHOD
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United States of America Patent
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Jul 16, 2002
Grant Date -
Jul 25, 2002
app pub date -
Jan 24, 2001
filing date -
Oct 11, 1996
priority date (Note) -
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Abstract
The present invention features a method of producing a multimeric protein from a hybrid cell formed from the fusion of two or more cells, each of which cell is engineered to express one component of the multimeric protein, as well as a method for screening for successful fusion of the cells to produce a desired hybrid cell. The methods of the invention are widely applicable to the production of proteins having two or more components.
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